Publications by authors named "Crista Minderhoud"
Article Synopsis
- - This study focuses on understanding how disease characteristics and quality of life evolve across different life stages for individuals with Dravet syndrome and related seizure disorders, aiming to help doctors provide better personalized care.
- - Researchers gathered data through questionnaires, medical records, and interviews, tracking changes in health-related quality of life over a seven-year period, with particular attention to how different factors impact patient well-being.
- - Findings show that Dravet syndrome patients reported lower quality of life compared to those with non-Dravet conditions, although older Dravet patients exhibited improved quality of life, which was linked to fewer behavioral issues and better physical independence.
Background: A pathogenic variant in SCN1A can result in a spectrum of phenotypes, including Dravet syndrome (DS) and genetic epilepsy with febrile seizures plus (GEFS + ) syndrome. Dravet syndrome (DS) is associated with refractory seizures, developmental delay, intellectual disability (ID), motor impairment, and challenging behavior(1,2). GEFS + is a less severe phenotype in which cognition is often normal and seizures are less severe.
View Article and Find Full Text PDFAims: We addressed the question whether chronic kidney disease (CKD) may contribute to cognitive decline in type 2 diabetes.
Methods: Participants with type 2 diabetes with elevated cardiovascular risk or CKD from cognition substudies of two large trials were studied prospectively (CARMELINA: n = 2666, mean ± SD age 68.1 ± 8.
Aims: Clopidogrel is used as secondary prevention after cerebral ischaemia. Previous, mainly Asian, studies have shown that genetic variations in CYP2C19 are associated with an increased risk of recurrent stroke in clopidogrel-treated patients. Evidence on the impact of this drug-gene interaction in European neurology patients is currently limited.
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