Tritium decay catastrophe.

The phenomenon of tritium decay catastrophe is introduced. A technical example is provided regarding the radioligand [methoxy-H] levosulpiride whose long-term behavior is consistent with the concept of tritium decay catastrophe.

Prediction and Discovery of Cannabidiol Crystal Polymorph Form 2.

The article puts into perspective the recent discovery of cannabidiol crystal polymorph Form 2.

Luminescence enhancement by deuterium.

Created literally at the dawn of time, deuterium has been extremely valuable in so many chemistry roles. The subject of this review focuses on one deuterium application in particular: its enhancement of luminescence in many substances. After providing general overviews of both deuterium and luminescence, the early exploration of deuterium's effect on luminescence is described, followed by a number of specific topics.

Cannabinoid Photochemistry: An Underexplored Opportunity.

Photochemistry is a powerful synthetic tool resulting in the construction of unique substances. Remarkably, photochemistry has been relatively underexplored in the cannabinoid area and represents a valuable opportunity for further discovery.

Radiolabelling of bisphenol A and several related analogues.

This paper describes the synthesis and characterization of bisphenol A and several closely associated derivatives with C and tritium.

Cannabinoid crystal polymorphism.

Because cannabinoids are usually amorphous solids, the thought that some of them may also exist in distinctly different crystal polymorphic forms might at first seem unusual. However, this commentary provides compelling evidence and precedent for the likely existence of cannabinoid crystal polymorphism.

A synthesis of [ C]formamidine acetate.

The one-step synthesis of [ C]formamidine acetate from [ C]barium cyanamide is described with product characterization by TLC and proton NMR.

Delta-9-Tetrahydrocannabinolic Acid B: A Mechanism for its Formation in .

There appears to be consensus among biologists that delta-9-tetrahydrocannabinolic acid A (THCA-A) is the exclusive product of the enzyme THCA synthase. This then leaves an open question for formation of the THCA-A structural isomer, delta-9-tetrahydrocannabinolic acid B (THCA-B), discovered as a minor product in in 1969. With no reasonable biochemical pathway to explain the presence of THCA-B in , a synthetic route was next considered.

Acidic Cannabinoid Decarboxylation.

is a valuable plant, cultivated by humans for millennia. However, it has only been in the past several decades that biologists have begun to clarify the interesting biosynthesis details, especially the production of its fascinating natural products termed acidic cannabinoids. Acidic cannabinoids can experience a common organic chemistry reaction known as decarboxylation, transforming them into structural analogues referred to as neutral cannabinoids with far different pharmacology.

MicroED and cannabinoid research.

MicroED has recently emerged as a convenient and powerful tool for the unequivocal structure determination of small molecules and it could likely be used in cannabinoid research as well.

Tritium labelling of two potent dopamine D receptor agonists at high specific activity.

An efficient method is described to radiolabel several dopamine D receptor agonists with tritium at high specific activity.

Chirality in Cannabinoid Research.

Mankind has long utilized for diverse purposes. However, it has only been since the late 19th century that its individual cannabinoids began to be isolated, analyzed, and synthesized. By the mid-20th century it was discovered that many cannabinoids were asymmetric, with chirality often controlling their pharmacology.

Minnesota wild hemp: a crucial botanical source in early cannabinoid discovery.

Renewed and sustained Cannabis chemistry exploration was initiated by Roger Adams at the University of Illinois Chemistry Department with cooperation from the Treasury Department Narcotics Laboratory in the early 1940's. This partnership and time investment by both parties made practical sense. Adams was able to explore natural products chemistry and the Narcotics Laboratory began to clarify the chemistry mysteries of Cannabis.

An effective and scalable C radiolabelling of several biogenic indole derivatives at high specific activity.

An efficient method is described to radiolabel several biogenic indole derivatives with carbon-14 at high specific activity.

S-(4-nitrobenzyl)-6-thioinosine: Tritium labelling at high specific activity.

The one-step tritiation of S-(4-nitrobenzyl)-6-thioinosine is described with characterization of the product by tritium NMR as well as mass spectrometry. The storage, stability, and repurification of [benzyl methylene- H]S-(4-nitrobenzyl)-6-thioinosine are also discussed.

An alternative and simple synthesis of [ C]potassium cyanate.

The one-step synthesis of [ C]potassium cyanate from [ C]urea is described with product characterization by gravimetric specific activity as well as a novel TLC system. The storage, stability, and repurification of [ C]potassium cyanate are also discussed.

A convenient synthesis of the muscarinic cholinergic antagonist (R)-[N-methyl- H]quinuclidinyl benzilate methiodide.

A useful synthesis of (R)-[N-methyl- H]quinuclidinyl benzilate methiodide is described with the product characterized by thin-layer chromatography (TLC), high-performance liquid chromatography (HPLC), tritium nuclear magnetic resonance (NMR), and mass spectrometry (MS). Several methods are provided to purify the radioligand, and its storage and stability are also discussed.

Spiperone: Tritium labelling at high specific activity.

An efficient method is described to tritiate spiperone at high specific activity.