Exploring the Shared Pathogenesis Mechanisms of Endometriosis and Cancer: Stemness and Targeted Treatments of Its Molecular Pathways-A Narrative Review.

Endometriosis is a benign disease but with malignant behavior, sharing numerous features with cancers. Endometriosis is the development of endometrial tissue outside the uterus, with the presence of both glands and stroma. Approximately 10% of women of reproductive age suffer from endometriosis; it involves high social costs and affects the patient's quality of life.

Unlocking Better Asthma Control: A Narrative Review of Adherence to Asthma Therapy and Innovative Monitoring Solutions.

This review addresses the ongoing challenges in asthma management, particularly focusing on patient adherence to inhaler therapy. Asthma, a chronic condition characterized by variable respiratory symptoms and airflow obstruction, can lead to significant morbidity and mortality if not properly managed. Despite advances in inhaler technology and therapeutic options, non-adherence remains a significant barrier to optimal asthma control.

Magnetic Memory Effects in BaFe(AsP) Superconducting Single Crystal.

Among many iron-based superconductors, isovalently substituted BaFe(AsP) displays, for ≈ 0.3, apart from the quite usual Second Magnetization Peak (SMP) in the field dependence of the critical current density, an unusual peak effect in the temperature dependence of the critical current density in the constant field, which is related to the rhombic-to-square (RST) structural transition of the Bragg vortex glass (BVG). By using multi-harmonic AC susceptibility investigations in three different cooling regimes-field cooling, zero-field cooling, and field cooling with measurements during warming up-we have discovered the existence of a temperature region in which there is a pronounced magnetic memory effect, which we attributed to the direction of the structural transition.

From Dashboard Zoo to Census: A Case Study With Tableau Public.

Dashboards remain ubiquitous tools for analyzing data and disseminating the findings. Understanding the range of dashboard designs, from simple to complex, can support development of authoring tools that enable end-users to meet their analysis and communication goals. Yet, there has been little work that provides a quantifiable, systematic, and descriptive overview of dashboard design patterns.

High Magnetic Performance in MnGa Nanocomposite Magnets.

In view of their potential applicability in technology fields where magnets are required to operate at higher temperatures, the class of nanocomposite magnets with little or no rare earth (RE) content has been widely researched in the last two decades. Among these nanocomposite magnets, the subclass of magnetic binary systems exhibiting the formation of L1 tetragonal phases is the most illustrious. Some of the most interesting systems are represented by the Mn-based alloys, with addition of Al, Bi, Ga, Ge.

Expanding the Manufacturing Approaches for Gastroretentive Drug Delivery Systems with 3D Printing Technology.

Gastroretentive drug delivery systems (GRDDSs) have gained substantial attention in the last 20 years due to their ability to retain the drug in the stomach for an extended time, thus promoting an extended release and high bioavailability for a broad range of active pharmaceutical ingredients (APIs) that are pH-sensitive and/or have a narrow absorption window. The currently existing GRDDSs include floating, expanding, mucoadhesive, magnetic, raft-forming, ion-exchanging, and high-density systems. Although there are seven types of systems, the main focus is on floating, expanding, and mucoadhesive systems produced by various techniques, 3D printing being one of the most revolutionary and currently studied ones.

The Role of DNA Repair (, , , and Gene Polymorphisms in the Development of Myeloproliferative Neoplasms.

: Several polymorphisms have been described in various DNA repair genes. Nucleotide excision DNA repair (NER) detects defects of DNA molecules and corrects them to restore genome integrity. We hypothesized that the , , , and gene polymorphisms influence the appearance of myeloproliferative neoplasms (MPNs).

Polyvinyl Alcohol, a Versatile Excipient for Pharmaceutical 3D Printing.

Three-dimensional (3D) printing in the pharmaceutical field allows rapid manufacturing of a diverse range of pharmaceutical dosage forms, including personalized items. The application of this technology in dosage form manufacturing requires the judicious selection of excipients because the selected materials must be appropriate to the working principle of each technique. Most techniques rely on the use of polymers as the main material.

A Narrative Review of Self-Reported Scales to Evaluate Depression and Anxiety Symptoms in Adult Obstructive Sleep Apnea Patients.

: Obstructive sleep apnea (OSA) is a prevalent chronic condition that has been associated with mental disorders like depression and anxiety. This study intends to provide a practical overview of the most relevant self-reported and self-rating scales that assess depression and anxiety in OSA patients. : A search for articles was performed using PubMed, Google Scholar, and Semantic Scholar using a combination of words for obstructive sleep apnea, depression, anxiety, and scales.

Endometriosis and the Role of Pro-Inflammatory and Anti-Inflammatory Cytokines in Pathophysiology: A Narrative Review of the Literature.

Endometriosis is a chronic inflammatory disease, which explains the pain that such patients report. Currently, we are faced with ineffective, non-invasive diagnostic methods and treatments that come with multiple side effects and high recurrence rates for both the disease and pain. These are the reasons why we are exploring the possibility of the involvement of pro-inflammatory and anti-inflammatory molecules in the process of the appearance of endometriosis.

Large Lung Consolidation: A Rare Presentation of Pulmonary Sarcoidosis.

Sarcoidosis is a complex inflammatory disease of uncertain origin, characterized by non-necrotizing epithelioid cell granulomas (NNEGs) affecting multiple organ systems. Although many different clinical and pathological phenotypes can be present, with different organs involved, the lung is the most common site described. In this case report, we (a) present and discuss the broad differential diagnosis of a patient presenting with a solitary lung mass with clinical and imaging features of lung cancer that ultimately was confirmed with a rare manifestation of stage II pulmonary sarcoidosis, and (b) analyze and compare similar cases from the literature.

Remarkable Magnetic Properties in a MnGa Alloy Produced via Out-of-Equilibrium Method.

Rare-earth-free permanent magnets with the L1 phase are actively researched for their potential as a future class of magnetic materials, capable of operating at higher temperatures and in challenging corrosion environments such as renewable energy applications. Among these classes, MnGa shows potential, being cost effective and having interesting magnetic properties. A MnGa magnetic alloy, with composition MnGa in atomic percent, was produced via the out-of-equilibrium method, and its structural and magnetic properties were assessed using X-ray diffraction (XRD), transmission electron microscopy (TEM), selected area electron diffraction (SAED) and extended magnetic characterization.

Eliciting Model Steering Interactions From Users via Data and Visual Design Probes.

Visual and interactive machine learning systems (IML) are becoming ubiquitous as they empower individuals with varied machine learning expertise to analyze data. However, it remains complex to align interactions with visual marks to a user's intent for steering machine learning models. We explore using data and visual design probes to elicit users' desired interactions to steer ML models via visual encodings within IML interfaces.

Development of a Bilayer Tablet by Fused Deposition Modeling as a Sustained-Release Drug Delivery System.

Three-dimensional printing by fused deposition modeling (FDM) coupled with hot-melt extrusion (HME) is a point of convergence of research efforts directed toward the development of personalized dosage forms. In addition to the customization in terms of shapes, sizes, or delivered drug doses, the modulation of drug release profiles is crucial to ensure the superior efficacy and safety of modern 3D-printed medications compared to those of conventional ones. Our work aims to solidify the groundwork for the preparation of 3D-printed tablets that ensure the sustained release of diclofenac sodium.

The Role Played by Novel Inflammatory Markers in Assessment of Peripheral Artery Disease.

: Atherosclerosis is a multifactorial process in which inflammatory markers have both therapeutic and prognostic roles. Recent studies bring into question the importance of assessing new inflammatory markers in relation to the severity of peripheral artery disease (PAD), such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and lymphocyte-to-C-reactive protein ratio (LCR). : We conducted a retrospective and descriptive study including 652 patients with PAD, who were divided into two groups according to the severity of the ankle-brachial index value: mild and moderate obstruction (257 patients) and severe obstruction (395 patients).

Development of Diclofenac Sodium 3D Printed Cylindrical and Tubular-Shaped Tablets through Hot Melt Extrusion and Fused Deposition Modelling Techniques.

The present study aimed to develop 3D printed dosage forms, using custom-made filaments loaded with diclofenac sodium (DS). The printed tablets were developed by implementing a quality by design (QbD) approach. Filaments with adequate FDM 3D printing characteristics were produced via hot melt extrusion (HME).

Exploring Patient Adherence to Post-Surgical Follow-Up in Pelvic Endometriosis.

Endometriosis is a significant cause of disability that affects 5-10% of reproductive-aged women. Laparoscopy with histological confirmation is the gold standard in establishing the diagnosis as therapeutic management surgery is addressed to a certain category of patients. The objective of this study was to assess patient adherence to follow-up after surgery for endometriosis as the primary endpoint, pain symptoms, quality of life, mental health, and fertility as the secondary endpoints.

A Systematic Review of Telemedicine-Driven Pulmonary Rehabilitation after the Acute Phase of COVID-19.

The acute phase of COVID-19 often leaves patients with persistent pulmonary deficits. Pulmonary Rehabilitation (PR) has been recommended as an essential part of post-acute COVID-19 management. In light of the global pandemic, telerehabilitation has been increasingly employed to deliver PR.

Vortex Glass-Vortex Liquid Transition in BaFe(AsP) and CaKFeAs Superconductors from Multi-Harmonic AC Magnetic Susceptibility Studies.

For practical applications of superconductors, understanding the vortex matter and dynamics is of paramount importance. An important issue in this context is the transition of the vortex glass, which is a true superconducting phase, into a vortex liquid phase having a linear dissipation. By using multi-harmonic susceptibility studies, we have investigated the vortex glass-vortex liquid phase transitions in CaKFeAs and BaFe(AsP) single crystals.

Novel Rare Earth (RE)-Free Nanocomposite Magnets Derived from L1-Phase Systems.

In the quest for novel rare earth (RE)-free magnetic materials, which also exhibit other additional properties such as good corrosion resistance and potential to operate at higher temperatures, an alloy deriving from the binary FePt system, with Mo and B addition, has been synthesized for the first time, using the out-of-equilibrium method of rapid solidification form the melt. The alloy with the composition FePtMoB has been subjected to thermal analysis through differential scanning calorimetry in order to detect the structural disorder - order phase transformation as well as to study the crystallization processes. For the stabilization of the formed hard magnetic phase, the sample has been annealed at 600 °C and further structurally and magnetically characterized by means of X-ray diffraction, transmission electron microscopy, Fe Mössbauer spectrometry as well as magnetometry experiments.

Subtle Immunoreactivity Differences in the Fractal Patterns of Membrane E-Cadherin in Gastric Adenocarcinoma.

Gastric cancer continues to be a significant malignancy worldwide, accounting for approximately one million new cases in 2020. Scientists are focusing on the cancerous cells' plasma membrane (PM) as a potential therapeutic target in cancer because it functions as the cell's interface with its environment through a variety of mechanisms. The capacity of membrane shape and its structures to influence biological processes frequently occurs through the regulation of enzymes or preferential protein binding to membranes via membrane shape changes.