Chronic suppurative otitis media and related complications at the University Clinic of Kinshasa.

During the five-year period from 1998 to 2002, the ENT department of the University Clinic of Kinshasa treated 343 patients suffering from chronic suppurative otitis media (CSOM) and complications. Two hundred and seven patients had simple, 28 had cholesteatomatous form of CSOM, and 108 patients presented with intratemporal or intracranial complications. Roughly half of the patient group consisted of children younger than 10 years.

Clinical evaluation of conversational speech fluency in the acute phase of acquired childhood aphasia: does a fluency/nonfluency dichotomy exist?

Traditional neurologic tenets claim that the clinical picture of acquired childhood aphasia is nonfluent irrespective of lesion location. In the past 20 years, however, several case studies have shown that fluent aphasic patterns can be observed in children with acquired childhood aphasia. But the question remains open as to whether the pattern of their speech characteristics is similar to the one described in adult aphasics as studies addressing spontaneous speech fluency characteristics in larger series of children with acquired childhood aphasia are scarce.

Morphometric analysis of the uvula in patients with sleep-related breathing disorders.

The upper-airway mucosa in obstructive sleep apnea (OSA) patients and snorers is often described as edematous and hyperplastic. The morphologic aspects of the pharyngeal mucosa, and in particular the mucosa of the uvula and soft palate, in OSA patients are, however, not well described. The aim of the present retrospective study therefore was to perform histologic examination of the pharyngeal mucosa obtained from patients with various forms of sleep-related breathing disorders, including primary snoring.

Line bisection performances of 650 normal children.

When bisecting lines, an important number of brain damaged patients tend to place their bisection marks in the hemispace ipsilateral to their lesion. Biases have also been reported in normal adults. In vertical bisection both patients and normal subjects present with upward shifts, although a downward displacement may occur eventually.

Clinical utility of the judgment of line orientation test and facial recognition test in children with acquired unilateral cerebral lesions.

In unselected adult patients with brain damage, the Judgment of Line Orientation Test and the Facial Recognition Test are considered valid instruments for detecting right cerebral hemisphere lesions. It is unknown, however, whether this applies to children as well. Performance levels on the Judgment of Line Orientation Test and the Facial Recognition Test of 18 children with acquired left cerebral lesions and 14 children with acquired right cerebral lesions were reviewed.

Extracellular proteins and virulence in Streptococcus bovis isolates from pigeons.

The association between virulence and the occurrence of the extracellular proteins A, T1, T2 and T3 in the culture supernatant of pigeon Streptococcus bovis strains, was examined in experimental infection studies. Fourteen groups of 10-17 pigeons were inoculated intravenously with 1 x 10(9) CFU of S. bovis strains that belonged to the phenotypes A + T1, A - T1, A + T2, A - T2, A + T3 and A - T3, respectively.

Treatment of patent ductus arteriosus with ibuprofen.

Aim: To evaluate the efficiency and side effects of ibuprofen for the early treatment of patent ductus arteriosus (PDA) and compare it with indomethacin.

Methods: Forty preterm infants with gestational ages of less than 33 weeks, with respiratory distress syndrome (RDS) and echocardiographically confirmed PDA, were randomly assigned at days 2 to 3 of life to receive either intravenous indomethacin 3 x 0.2 mg/kg at 12 hour intervals or intravenous ibuprofen 1 x 10 mg/kg, followed by 5 mg/kg 24 and 48 hours later.

Study of the bronchodilating effect of three doses of nebulized oxitropium bromide in asthmatic preschool children using the forced oscillation technique.

Unlabelled: The aim of this study was to evaluate the bronchodilating capacity of nebulized oxitropium bromide (OB) in preschool asthmatic children and to determine an appropriate dose for usage in this age group. The trial enrolled 20 patients with moderate to severe stable asthma aged between 3.2 and 6.

Functional residual capacity in healthy preschool children.

The purpose of this study was to evaluate the feasibility of routine functional residual capacity (FRC) measurements in healthy preschool children aged 2.7-6.4 yrs.

An analysis of spontaneous conversational speech fluency in children with acquired aphasia.

We report on an instrumental analysis of spontaneous conversational speech (SCS) fluency in acquired childhood aphasia (ACA). Tape-recorded SCS samples of 25 children with ACA (clinical judgment: 12 nonfluent and 13 fluent), and of 12 dysarthric and 12 nonaphasic and nondysarthric right hemisphere injured children were analysed in order to: (1) investigate whether a more refined analysis can objectively contribute to the differentiation of patients who were labelled as fluent or nonfluent on the basis of a clinical judgment: (2) verify whether an instrumental analysis of phonation duration does confirm the subjective estimation of verbal rate (i.e.

Transient musical hallucinosis of central origin: a review and clinical study.

A 52 year old, right handed, hearing impaired woman was admitted with headache and neck stiffness. The only neuropsychological symptom was transient auditory perceptions in the left ear, which were musical, seemed familiar and were not influenced by verbal communication. CT and MRI showed a right subarachnoid haemorrhage, while brainstem auditory evoked potentials failed to reveal a brainstem lesion.

Side effects of repeated ototopical application of fosfomycin. An animal study.

In view of the possible role of fosfomycin in the topical treatment of chronic suppurative otitis media, the effects of this drug on inner ear function were investigated. Fosfomycin (20% aqueous solution) was applied repeatedly to the round window membrane of both ears of pigmented guinea pigs. Hearing thresholds were determined by daily frequency-specific evoked response audiometry with stimulation frequencies ranging from 1 to 32 kHz.

Psychoacoustical tuning curves. Normative data for clinical use.

This normative study presents a clinically applicable method with which to obtain Psychoacoustical Tuning Curves: data are obtained with clinical audiometers, and measurements are performed on normal-hearing non-trained volunteers. A simultaneous masking method with test frequency of 4,000 Hz was used, withmasking being incremented in 5 dB or 1 dB steps. One group of subjects was tested three times with 5 dB incrementing steps to evaluate the method's reproducibility.

Allograft tympanoplasty: predictive value of preoperative status.

The functional and anatomical results of a series of 181 consecutive allograft tympanoplasties for ears with drum perforation and an intact ossicular chain were retrospectively reviewed and related to preoperative factors. Drum closure was realized in 92% (166 of 181 cases evaluated 1 year after surgery), and 96.6% of the reconstructed drums were still intact 3 years after surgery (118 cases evaluated).

Histamine nasal provocation test. An evaluation of active anterior rhinomanometry and of threshold criteria of provocative dose.

This study is a methodological approach to histamine nasal provocation. The test uses active anterior rhinomanometry and a histamine titration method, challenging both nasal cavities with a metered dose pump. It has been confirmed that the histamine nasal provocation test can differentiate between controls and non-allergic rhinitis patients.

Effect of topical levocabastine on allergic and non-allergic perennial rhinitis. A double-blind study, levocabastine vs. placebo, followed by an open, prospective, single-blind study on beclomethasone.

Forty-four patients, with symptoms of nasal obstruction, sneezing, itching and/or rhinorrhea, were entered into a placebo-controlled, double-blind study to evaluate the clinical efficacy of a topical antihistamine drug, levocabastine, applied 4 times a day for 14 days. At the end of the treatment the placebo patients were treated with levocabastine and the levocabastine patients were treated with beclomethasone dipropionate in a single-blind design for another 14 days. This study showed that levocabastine is significantly more active than placebo with reference to nasal discharge and sneezing.

Hypertension in obese and non-obese non-insulin dependent diabetics a matter of regional adiposity?

There is growing evidence that differences in fat distribution can be predictive for differences in the prevalence of metabolic disturbances, cardio-vascular disease, stroke and death, independent of commonly used indices of obesity. This study evaluates regional body fat distribution as a possible main reason for hypertension in obese and non-obese type II diabetics. 42% of normal weight diabetics with abdominal obesity are hypertensive versus 47% of obese diabetics; only 5% hypertension could be found when a lower body segment fat distribution is present.

Relationship of body fat distribution pattern to atherogenic risk factors in NIDDM. Preliminary results.

Because recent knowledge indicates that the distribution of fat deposits in men may be a better predictor of cardiovascular disease than the degree of obesity alone, some risk factors for atherosclerosis were evaluated in 51 middle-aged men with non-insulin-dependent diabetes mellitus. Abdominal adiposity (waist/hip ratio, WHR) was related to parameters of metabolic control, lipid parameters, and known vascular complications in three different groups. In groups with abdominal obesity, mean annual hemoglobin A1 was significantly (P less than .

Immittance audiometry. Normative data at 220 and 660 Hz.

Normative immittance data for normal ears were collected at 220 and 660 Hz probe tone frequencies. The experimental set-up enabled conversion of simultaneously recorded susceptance and conductance data to resistance, reactance, admittance and phase angle tympanograms. Special attention was given to the subtraction of the ear canal admittance and to the pump speed.

Multifrequency tympanometry in normal ears.

Susceptance and conductance tympanograms were recorded from 10 normal subjects with probe frequencies ranging from 220 to 910 Hz. Tympanometric shapes progressed through an orderly sequence of patterns, becoming more complex with increasing probe frequency. When the direction of ear-canal air pressure change was from negative to positive values, more complicated tympanometric shapes occurred for all subjects, compared to the positive to negative direction.

Tympanometric middle-ear pressure determination with two-component admittance meters.

Exact tympanometric determination of the middle-ear pressure based on the location of the (central) extremum of susceptance, conductance, admittance, impedance, reactance or phase-angle tympanograms is not possible. None of these immittance components reaches its extremum exactly at middle-ear pressure neither at 220 nor at 660 Hz, due to the hysteresis caused by the viscoelastic behaviour of the soft biological tissue of the middle-ear structures. These effects cannot be avoided by lowering the rate of the pressure change during the recordings.

A search for the most suitable imminent components and probe tone frequency in tympanometry.

The relative occurrence of bell-shaped and various types of W-shaped susceptance-conductance and admittance-phase tympanograms at a probe-tone frequency of 660 Hz was determined from registrations on normal ears. The diagnostic value of the susceptance-conductance versus the admittance-phase representation of tympanograms was studied on pathological middle-ear systems. Using probe-tone frequencies from 510 Hz up to 910 Hz, tympanograms for all four imminent components were recorded on 10 pathological ears and the diagnostic value compared.

Optimizing tympanometric variables for detecting middle ear traumas.

The combination of the results of different studies lead to the conclusion that the susceptance-conductance immittance audiometer at 660 Hz is not the only useful instrument for the detection of middle-ear traumas. Measurements at probe-tone frequencies from 510 up to 910 Hz prove that the admittance tympanogram combined with the electrical phase angle tympanogram recorded in the 500-700 Hz frequency range have definite advantages.

Incudo-stapedial joint pathology: a tympanometric approach.

Two-component tympanometry with a high probe-tone frequency enables a better distinction to be made between mobile but normal middle-ear systems and middle-ear systems suffering from necrosis, luxation, or disruption. Susceptance and conductance tympanograms obtained from 14 patients with confirmed pathological middle-ear lesions and 8 postmortem temporal bones, experimentally manipulated either surgically or with a 1 N HCl solution, were compared to tympanograms obtained from 80 normal subjects of an earlier study. With a 660-Hz probe tone, normal middle ears generate bell-shaped or normal sharp W-shaped patterns, whereas the pathologies of the middle ear give rise to irregular multi-extrema tympanograms.