Serum concentrations of gabapentin in cats with chronic kidney disease.

Objectives: The purpose of this study was to assess serum concentrations of gabapentin in cats with chronic kidney disease (CKD) vs clinically healthy cats.

Methods: Five healthy cats were enrolled in a pharmacokinetic study. A single 20 mg/kg dose of gabapentin was administered orally and blood was obtained at 0, 0.

Vitamin C in Health and Disease: A Companion Animal Focus.

Vitamin C is synthesized in the liver in most species, including dogs and cats, and is widely distributed through body tissues. Vitamin C has an important physiologic role in numerous metabolic functions including tissue growth and maintenance, amelioration of oxidative stress, and immune regulation. It is also a co-factor in the production of important substances such as catecholamines and vasopressin.

Evaluation of two point-of-care ethylene glycol tests for dogs.

Objective: To evaluate 2 point-of-care ethylene glycol (EG) tests in dogs.

Design: Prospective, randomized, blinded laboratory evaluation.

Setting: University teaching hospital.

Indigenous lands, protected areas, and slowing climate change.

Recent climate talks in Copenhagen reaffirmed the crucial role of reducing emissions from deforestation and degradation (REDD). Creating and strengthening indigenous lands and other protected areas represents an effective, practical, and immediate REDD strategy that addresses both biodiversity and climate crises at once.

Sporadic corticobasal syndrome due to FTLD-TDP.

Sporadic corticobasal syndrome (CBS) has been associated with diverse pathological substrates, but frontotemporal lobar degeneration with TDP-43 immunoreactive inclusions (FTLD-TDP) has only been linked to CBS among progranulin mutation carriers. We report the clinical, neuropsychological, imaging, genetic, and neuropathological features of GS, a patient with sporadic corticobasal syndrome. Genetic testing revealed no mutations in the microtubule associated protein tau or progranulin (PGRN) genes, but GS proved homozygous for the T allele of the rs5848 PGRN variant.

Effect of prebreeding body weight or progestin exposure before breeding on beef heifer performance through the second breeding season.

Two experiments evaluated prebreeding target BW or progestin exposure for heifers developed lighter than traditional recommendations. Experiment 1 evaluated the effects of the system on heifer performance through subsequent calving and rebreeding over 3 yr. Heifers (229 kg) were assigned randomly to be developed to 55% of mature BW (299 kg) before a 45-d breeding season (intensive, INT; n = 119) or 50% of mature BW (272 kg) before a 60-d breeding season (relaxed, RLX; n = 142).

Undegradable intake protein supplementation of compensating spring-born steers and summer-born steers during summer grazing.

Three trials were conducted to determine the effects of previous winter gain (Trials 1 and 3) and age of calf (Trials 1 and 2) on response to undegradable intake protein (UIP) supplementation during summer grazing. In Trial 1, 48 spring-born steers (243 kg) were used in a 4 x 2 factorial arrangement. Steers were wintered at four rates of gain: 0.

Effects of varying levels of undegradable intake protein on endocrine and metabolic function of young post-partum beef cows.

Twelve Hereford x Angus heifers, 2.5 year, 492 +/- 17 kg (BCS = 5 +/- 0.5), were randomly assigned to one of three supplements, stratified by calving date and calf sex.

Lymphokine production during term human pregnancy: differences between peripheral leukocytes and decidual cells.

Although the fetus is considered to be an "allograft" there is little information concerning the role of lymphokines in human pregnancy. Lymphokines are polypeptides secreted by stimulated lymphocytes that direct the immune response by enabling immune effector cells to communicate with each other. To characterize lymphokine production during normal human pregnancy, we isolated peripheral leukocytes and decidual lymphocyte-like cells from women undergoing repeat cesarean section at term.

Immunoglobulin G fractions from patients with antiphospholipid antibodies cause fetal death in BALB/c mice: a model for autoimmune fetal loss.

We determined whether purified immunoglobulin G from patients with antiphospholipid antibodies causes fetal loss in pregnant mice. Sera were obtained from nonpregnant parous women (group 1) and nonpregnant women with antiphospholipid antibodies and a history of fetal loss (group 2). Pregnant BALB/c mice were given an intraperitoneal injection of 15 mg of IgG on day 8 of pregnancy.