Sugar-sweetened beverage consumption and vascular function in Hispanic and non-Hispanic males.

Hispanic men have one of the highest consumptions of sugar-sweetened beverages in the United States. Frequent sugar-sweetened beverage consumption has been associated with higher incidence of cardiovascular disease through altered vascular function. Cardiovascular disease is the second leading cause of death in the Hispanic population.

The influence of receiving real-time visual feedback on breathing during treadmill running to exhaustion.

Breathing plays a vital role in everyday life, and specifically during exercise it provides working muscles with the oxygen necessary for optimal performance. Respiratory inductance plethysmography (RIP) monitors breathing through elastic belts around the chest and abdomen, with efficient breathing defined by synchronous chest and abdomen movement. This study examined if providing runners with visual feedback through RIP could increase breathing efficiency and thereby time to exhaustion.

Examining Contributors to Intent to Continue Exercising in Patients With Cancer in Rehabilitation.

Background: Exercise is physiologically and psychologically beneficial to cancer survivors, leading to an increase in supervised exercise programs targeting this population. However, more than half of survivors who are offered a supervised exercise program do not complete it.

Objectives: The purpose of this study was to determine which factors influence survivors' decisions to continue exercising in or outside of a supervised exercise program using the theory of planned behavior (TPB).

Cumulative oral examinations in undergraduate human physiology: process, student perceptions, and outcomes.

Assessment methods vary widely across undergraduate physiology courses. Here, a cumulative oral examination was administered in two sections of a 300-level undergraduate physiology course. Student performance was quantified via instructor grading using a rubric, and self-perceptions ( = 55) were collected via survey.

The 2019 P-MIG Student Survey report and capturing the undergraduate perspective of physiology programming.

The aim of the 2019 Student Survey was to inform the Physiology Majors Interest Group (P-MIG) of characteristics of undergraduates enrolled in physiology courses or degree programs from across the United States, to be used as one input source for the development of program-level guidelines. There were 1,389 participants from seven universities who completed the 2019 P-MIG Student Survey. Thirty-seven percent reported enrollment in a physiology/human physiology major; allied health-related programs were the second most common (24%).

Advising physiology students: perceptions from the programs.

Academic advising outcomes can be linked to both student success and retention. Yet relatively little is known specifically related to advising in physiology programs. Professional organizations dedicated to academic advising in general, and more specifically advising future health professional students exist, yet, whether current physiology programs utilize these resources remains unknown, as does a number of other demographic information about advising in physiology programs.

The theory of planned behavior and strength training in college-aged women.

Using Theory of Planned Behavior, the objective of this study was to determine how attitudes, subjective norms and perceived behavior control related to intent to strength training by college-aged women. Participants were college-aged females ( = 162) from a mid-sized private university in the Midwestern United States who were divided into three groups: non-exercisers, cardiovascular-only exercisers, and strength or strength and cardiovascular exercisers. Participants completed a questionnaire assessing attitudes, subjective norms and perceived behavior control in relation to strength training behavior.

Effects of Single-Dose Dietary Nitrate on Oxygen Consumption During and After Maximal and Submaximal Exercise in Healthy Humans: A Pilot Study.

Dietary nitrate (NO) has been shown to reduce oxygen consumption (VO) during moderate to high-intensity (e.g. time to fatigue, time trials) exercise and often in trained athletes.

Inhibition of Na /K -ATPase and K channels abolishes hypoxic hyperaemia in resting but not contracting skeletal muscle of humans.

Key Points: Increasing blood flow (hyperaemia) to exercising muscle helps match oxygen delivery and metabolic demand. During exercise in hypoxia, there is a compensatory increase in muscle hyperaemia that maintains oxygen delivery and tissue oxygen consumption. Nitric oxide (NO) and prostaglandins (PGs) contribute to around half of the augmented hyperaemia during hypoxic exercise, although the contributors to the remaining response are unknown.

Land-use and fire drive temporal patterns of soil solution chemistry and nutrient fluxes.

Land-use type and ecosystem disturbances are important drivers for element cycling and bear the potential to modulate soil processes and hence ecosystem functions. To better understand the effect of such drivers on the magnitude and temporal patterns of organic matter (OM) and associated nutrient fluxes in soils, continuous flux monitoring is indispensable but insufficiently studied yet. We conducted a field study to elucidate the impact of land-use and surface fires on OM and nutrient fluxes with soil solution regarding seasonal and temporal patterns analyzing short (<3months) and medium-term (3-12months) effects.

In situ monitoring of molecular changes during cell differentiation processes in marine macroalgae through mass spectrometric imaging.

Matrix-assisted laser desorption/ionization mass spectrometric imaging (MALDI-MSI) was employed to discriminate between cell differentiation processes in macroalgae. One of the key developmental processes in the algal life cycle is the production of germ cells (gametes and zoids). The gametogenesis of the marine green macroalga Ulva mutabilis (Chlorophyta) was monitored by metabolomic snapshots of the surface, when blade cells differentiate synchronously into gametangia and giving rise to gametes.

Spatial and Temporal Localization of Flavonoid Metabolites in Strawberry Fruit (Fragaria × ananassa).

Flavonoids are important metabolites in strawberries (Fragaria × ananassa) because they accomplish an extensive collection of physiological functions and are valuable for human health. However, their localization within the fruit tissue has not been extensively explored. Matrix-assisted laser desorption/ionization mass spectrometric imaging (MALDI-MSI) was employed to shed light on the spatial distribution of flavonoids during fruit development.

Tracing the fate and transport of secondary plant metabolites in a laboratory mesocosm experiment by employing mass spectrometric imaging.

Mass spectrometric imaging (MSI) has received considerable attention in recent years, since it allows the molecular mapping of various compound classes, such as proteins, peptides, glycans, secondary metabolites, lipids, and drugs in animal, human, or plant tissue sections. In the present study, the application of laser-based MSI analysis of secondary plant metabolites to monitor their transport from the grass leaves of Dactylis glomerata, over the crop of the grasshopper Chorthippus dorsatus to its excrements, and finally in the soil solution is described. This plant-herbivore-soil pathway was investigated under controlled conditions by using laboratory mesocosms.

Impaired peripheral vasodilation during graded systemic hypoxia in healthy older adults: role of the sympathoadrenal system.

Systemic hypoxia is a physiological and pathophysiological stress that activates the sympathoadrenal system and, in young adults, leads to peripheral vasodilation. We tested the hypothesis that peripheral vasodilation to graded systemic hypoxia is impaired in older healthy adults and that this age-associated impairment is due to attenuated β-adrenergic mediated vasodilation and elevated α-adrenergic vasoconstriction. Forearm blood flow was measured (Doppler ultrasound), and vascular conductance (FVC) was calculated in 12 young (24 ± 1 yr) and 10 older (63 ± 2 yr) adults to determine the local dilatory responses to graded hypoxia (90, 85, and 80% O saturations) in control conditions, following local intra-arterial blockade of β-receptors (propranolol), and combined blockade of α- and β-receptors (phentolamine + propranolol).

Physical and Psychological Effects of a 12-Session Cancer Rehabilitation Exercise Program.

Background: The positive effects of regular exercise for cancer survivors are becoming increasingly apparent. However, comprehensive examination of the benefits of modest levels of physical activity is somewhat lacking.

Objectives: This study aimed to test the hypothesis that participating in a 12-session exercise program will improve depression, fatigue, aerobic endurance, muscular strength, and quality of life (QOL) in patients with cancer.

Effect of ecosystem type and fire on chemistry of WEOM as measured by LDI-TOF-MS and NMR.

Soil organic matter (SOM) and its water-soluble components play an important role in terrestrial carbon cycling and associated ecosystem functions. Chemically, they are complex mixtures of organic compounds derived from decomposing plant material, microbial residues, as well as root exudates, and soil biota. To test the effect of the ecosystem type (forest and grassland) and fires events on the chemistry of dissolved organic matter (DOM), we applied a combination of laser-desorption/ionization time-of-flight mass spectrometry (LDI-TOF-MS) and 2D (H and C) nuclear magnetic resonance (NMR) spectroscopy to water-extractable organic matter (WEOM) from a range of top soil samples.

Health-Related Quality of Life Improves Similarly in Patients With and Without Type 2 Diabetes After Cardiac Rehabilitation.

Purpose: Cardiovascular disease is the leading cause of death in the United States and results in substantial healthcare expenditures. Health-related quality of life (HRQoL) is an important aspect in long-term recovery for patients with cardiovascular disease. As such, improvement in HRQoL is a relevant outcome for determining cardiovascular rehabilitation (CR) program efficacy.

MALDI mass spectrometric imaging meets "omics": recent advances in the fruitful marriage.

Matrix-assisted laser desorption/ionization mass spectrometric imaging (MALDI MSI) is a method that allows the investigation of the molecular content of surfaces, in particular, tissues, within its morphological context. The applications of MALDI MSI in the field of large-scale mass spectrometric studies, which are typically denoted by the suffix "omics", are steadily increasing. This is because, on the one hand, technical advances regarding sample collection and preparation, matrix application, instrumentation, and data processing have enhanced the molecular specificity and sensitivity of MALDI MSI; on the other hand, the focus of the "omics" community has moved from establishing an inventory of certain compound classes to exploring their spatial distribution to gain novel insights.

Acute ascorbic acid ingestion increases skeletal muscle blood flow and oxygen consumption via local vasodilation during graded handgrip exercise in older adults.

Human aging is associated with reduced skeletal muscle perfusion during exercise, which may be a result of impaired endothelium-dependent dilation and/or attenuated ability to blunt sympathetically mediated vasoconstriction. Intra-arterial infusion of ascorbic acid (AA) increases nitric oxide-mediated vasodilation and forearm blood flow (FBF) during handgrip exercise in older adults, yet it remains unknown whether an acute oral dose can similarly improve FBF or enhance the ability to blunt sympathetic vasoconstriction during exercise. We hypothesized that 1) acute oral AA would improve FBF (Doppler ultrasound) and oxygen consumption (V̇o2) via local vasodilation during graded rhythmic handgrip exercise in older adults (protocol 1), and 2) AA ingestion would not enhance sympatholysis in older adults during handgrip exercise (protocol 2).

Contracting human skeletal muscle maintains the ability to blunt α1 -adrenergic vasoconstriction during KIR channel and Na(+) /K(+) -ATPase inhibition.

Key Points: During exercise there is a balance between vasoactive factors that facilitate increases in blood flow and oxygen delivery to the active tissue and the sympathetic nervous system, which acts to limit muscle blood flow for the purpose of blood pressure regulation. Functional sympatholysis describes the ability of contracting skeletal muscle to blunt the stimulus for vasoconstriction, yet the underlying signalling of this response in humans is not well understood. We tested the hypothesis that activation of inwardly rectifying potassium channels and the sodium-potassium ATPase pump, two potential vasodilator pathways within blood vessels, contributes to the ability to blunt α1 -adrenergic vasoconstriction.

MALDI imaging-based classification of hepatocellular carcinoma and non-malignant lesions in fibrotic liver tissue.

Histopathologic differentiation of nodular lesions in cirrhotic liver is difficult even for experienced hepatopathologists especially regarding diagnosis of hepatocellular carcinoma (HCC) in biopsies. For this reason, new tissue markers are needed to reinforce histopathologic decision-making. With advances in molecular techniques, proteomic analysis may help to confirm the diagnosis of HCC.