Influence of oxaliplatin on 5-fluorouracil plasma clearance and clinical consequences.

Unlabelled: The influence of oxaliplatin (OXA) on 5-fluorouracil (5-FU) plasma clearance was investigated.

Patients And Methods: A group of 29 patients with advanced colorectal cancer refractory to prior weekly 8-h 5-FU infusion plus bolus folinic acid (FA), received the same combination plus OXA at 130 mg/m(2) every 3 weeks, OXA plus 5-FU plus FA on day 1, and 5-FU plus FA on days 8 and 15. Steady-state 5-FU concentrations in plasma were measured weekly and 5-FU clearance was calculated.