Design of a Re-Dispersible High Drug Load Amorphous Formulation.

Amorphous solid dispersions (ASD) are a commonly used enabling formulation technology to drive oral absorption of poorly soluble drugs. To ensure adequate solid-state stability and dissolution characteristics, the ASD formulation design typically has ≤ 25% drug loading. Exposed to aqueous media, ASD formulations can produce drug-rich colloidal dispersion with particle size < 500 nm.

Frustration and ennui among Amazon MTurk workers.

Academics are increasingly turning to crowdsourcing platforms to recruit research participants. Their endeavors have benefited from a proliferation of studies attesting to the quality of crowdsourced data or offering guidance on managing specific challenges associated with doing crowdsourced research. Thus far, however, relatively little is known about what it is like to be a participant in crowdsourced research.

Effects of Stereotype-Focused Imagined Contact on Young Adults' Intentions for Intergenerational Interaction.

Objectives: Face-to-face intergenerational contact is associated with more positive attitudes toward older adults. However, such contact can be difficult to achieve, and poor contact experiences can have negative consequences for intergenerational relations. We examined whether mentally simulated intergenerational contact (which is more easily facilitated and controllable) could reduce young adults' inclinations to avoid intergenerational interactions by increasing their inclusion of the older outgroup in the self (IOS), and by enhancing their stereotypes of older adults' warmth and competence.

Practical Guidance for Clinical Microbiology Laboratories: Diagnosis of Ocular Infections.

The variety and complexity of ocular infections have increased significantly in the last decade since the publication of , (L. D. Gray, P.

Sialadenoma Papilliferum: Analysis of Seven New Cases and Review of the Literature.

Sialadenoma papilliferum (SP) is a rare benign salivary gland neoplasm that comprises from 0.4 to 1.2% of all salivary gland tumors.

Experiences of "openness" between mothers and daughters during breast cancer: implications for coping and healthy outcomes.

Objective: Mother-daughter communication is central to how women adjust to breast cancer. They may be aided by models of healthy communication that illustrate both women's perspectives. Families establish normative communication patterns that inform how they cope.

High levels, partitioning and fish consumption based water guidelines of perfluoroalkyl acids downstream of a former firefighting training facility in Canada.

High levels of perfluoroalkyl acids (PFAAs), especially perfluorooctane sulfonic acid (PFOS), have been observed at locations in/around/downstream of the sites where PFOS-based firefighting foam was used repeatedly for a prolonged period. In this study, we conducted a detailed investigation of PFAA contamination in the Lake Niapenco area in Ontario, Canada, where among the highest ever reported levels of PFOS were recently measured in amphipods, fish and snapping turtle plasma. Levels and distribution of PFAAs in water, sediment and fish samples collected from the area varied widely.

Melanoma of the Oral Cavity: an Analysis of 46 New Cases with Emphasis on Clinical and Histopathologic Characteristics.

Melanoma of the oral cavity is a rare malignancy that carries a poor prognosis. We identified 46 new cases of both primary and metastatic melanoma to the oral cavity. Following IRB approval, these cases were obtained from the Oral Pathology Biopsy Service archives of the UF College of Dentistry (1994-2014), the UK College of Dentistry (1997-2015), and the UM Medical Center (1988-2015).

Desmoplastic Melanocytic Nevus of Oral Mucosa.

The desmoplastic melanocytic nevus is an uncommon variant that easily may be confused with a fibrohistiocytic neoplasm or a desmoplastic melanoma. It is believed that the following report describes the first known example of a desmoplastic melanocytic nevus arising in the oral mucosa. The histopathologic and immunohistochemical features that allow separation from other microscopically similar pathoses are stressed.

Optimal Management of Proliferative Verrucous Leukoplakia: A Systematic Review of the Literature.

Objective: Proliferative verrucous leukoplakia (PVL) is a rare and recalcitrant form of leukoplakia. The purpose of this review is to further characterize the risk factors, clinical course, and optimal treatment for this highly aggressive, premalignant lesion.

Data Sources: Twenty-six articles on PVL with a total of 329 PVL cases.

Effects of epidermal growth factor-loaded mucoadhesive films on wounded oral tissue rafts.

Current treatments for traumatic oral mucosal wounds include the gold standard of autologous tissue and alternative tissue-engineered grafts. While use of autografts has disadvantages of minimal availability of oral keratinized tissue, second surgery, and donor site discomfort, tissue-engineered grafts are limited by their unavailability as off-the-shelf products owing to their fabrication time of 4-8 weeks. Hence, the current work aimed to develop a potentially cost-effective, readily available device capable of enhancing native mucosal regeneration.

Neuroepithelial structures associated with the subepithelial nerve plexus of taste buds: a fortuitous finding resembling the juxtaoral organ of Chievitz.

Numerous embryologic epithelial remnants are described in the oral region, when intimately associated with peripheral nerves, may pose a diagnostic pitfall for pathologists. The literature contains cases in which the juxtaoral organ of Chievitz (JOC) was identified in specimens removed because of a malignancy and the correct recognition of this structure potentially avoids unnecessary treatment. To our knowledge, this is the description of neuroepithelial structures similar to the JOC were found in the posterior tongue in close association with the subepithelial nerve plexus of taste buds.

Communicative responses to the painful self-disclosures of familial and non-familial older adults.

Data from 365 college students were used to assess young adults' communicative responses to older persons' painful self-disclosures (PSDs). Coupland, Coupland, and Giles (1991) proposed that recipients of PSD may respond to such disclosures via a variety of"next moves." These responses may broadly be considered to reflect forms of pro-social engagement, passive disengagement, and active disengagement.

Ultrastructural analysis of the human lens fiber cell remodeling zone and the initiation of cellular compaction.

The purpose is to determine the nature of the cellular rearrangements occurring through the remodeling zone (RZ) in human donor lenses, identified previously by confocal microscopy to be about 100 μm from the capsule. Human donor lenses were fixed with 10% formalin followed by 4% paraformaldehyde prior to processing for transmission electron microscopy. Of 27 fixed lenses, ages 22, 55 and 92 years were examined in detail.

Older adults' evaluations of middle-aged children's attempts to initiate discussion of care needs.

We explored how older adults evaluated the strategies used by an adult child to initiate discussion of future care needs, and subsequently, whether these judgments affected older adults' willingness to engage in discussions about eldercare if approached in a similar fashion by one of their own children. One hundred and thirty older adults were randomly assigned to read one of four scripts depicting efforts by a middle-aged daughter to raise the topic of future care needs with her mother by implementing a variety of facework behaviors. Scripts manipulated the degree to which the daughter conveyed respect for her mother's desires for autonomy (negative face) and connection (positive face).

Dematiaceous fungi mimicking a conjunctival melanoma.

An 85-year-old, immunocompetent man was referred to the authors due to the presence of an enlarging, pigmented mass of the conjunctiva concerning for a conjunctival melanoma. Wide excision of the mass revealed a pigmented or "dematiaceous" fungus. He was treated with topical natamycin, and the lesion healed well without any evidence of recurrence.

Keratouveitis from Euphorbia cyparissias exposure is a temporal phenomenon.

We present the case of an 82-year-old woman with severe keratouveitis secondary to exposure to the plant Euphorbia cyparissias during the month of August. Despite copious irrigation of both eyes, she developed a case of Euphorbia keratouveitis that was typical in its course. Exposure to plant sap from this species should be treated much like an alkaline chemical injury as the pH of the ocular surface may be elevated.

Electron tomography of fiber cell cytoplasm and dense cores of multilamellar bodies from human age-related nuclear cataracts.

Human nuclear cataract formation is a multi-factorial disease with contributions to light scattering from many cellular sources that change their scattering properties over decades. The aging process produces aggregation of cytoplasmic crystallin proteins, which alters the protein packing and texture of the cytoplasm. Previous studies of the cytoplasmic texture quantified increases in density fluctuations in protein packing and theoretically predicted the corresponding scattering.

Glandular odontogenic cyst: analysis of 46 cases with special emphasis on microscopic criteria for diagnosis.

The glandular odontogenic cyst (GOC) is now a relatively well-known entity with recent reviews indicating over 100 cases reported in the English literature. The GOC's importance relates to the fact that it exhibits a propensity for recurrence similar to the odontogenic keratocyst, and that it may be confused microscopically with central mucoepidermoid carcinoma (CMEC). Numerous histopathologic features for the GOC have been described, but the exact microscopic criteria necessary for diagnosis have not been universally accepted.

Squamous odontogenic tumor-like proliferations in radicular cysts: a clinicopathologic study of forty-two cases.

Introduction: Squamous odontogenic tumor-like epithelial islands occurring in the walls of odontogenic cysts are histologically identical to the squamous odontogenic tumor (SOT). Microscopically, the squamous odontogenic tumor-like proliferations (SOTLPs) share certain histologic features with SOT, acanthomatous and desmoplastic ameloblastoma, and well-differentiated squamous cell carcinoma. Little is known about the rarely reported SOTLPs occurring in radicular cysts.

Case report: Diagnosis and treatment of a botryoid odontogenic cyst found in the maxillary anterior region.

Introduction: The botryoid odontogenic cyst (BOC) is a multicompartmentalized variant of the lateral periodontal cyst (LPC) that is typically found in the premolar-canine region of the mandible.

Methods: A 60-year old man was referred for evaluation of a radiolucent lesion discovered on a routine examination. Radiographs revealed a unilocular radiolucency between the roots of teeth #10 and #11.