Single vs 2-Stage Revision for the Treatment of Periprosthetic Joint Infection.

Periprosthetic joint infection (PJI) is one of the most devastating complications following total joint arthroplasty, accounting for a projected 10,000 revision surgeries per year by 2030. Chronic PJI is complicated by the presence of bacterial biofilm, requiring removal of components, thorough debridement, and administration of antibiotics for effective eradication. Chronic PJI is currently managed with single-stage or 2-stage revision surgery.

Cobalt-alloy implant debris induce HIF-1α hypoxia associated responses: a mechanism for metal-specific orthopedic implant failure.

The historical success of orthopedic implants has been recently tempered by unexpected pathologies and early failures of some types of Cobalt-Chromium-Molybdenum alloy containing artificial hip implants. Hypoxia-associated responses to Cobalt-alloy metal debris were suspected as mediating this untoward reactivity at least in part. Hypoxia Inducible Factor-1α is a major transcription factor involved in hypoxia, and is a potent coping mechanism for cells to rapidly respond to changing metabolic demands.

A case of disassociation of a modular femoral neck trunion after total hip arthroplasty.

Modular femoral heads offer the advantages of increased intraoperative flexibility through the adjustment of leg length and offset, whereas a modular femoral neck can also allow independent adjustment of femoral anteversion. Despite the potential advantages of hip systems using increased modularity, these component designs also offer a greater number of junctions through which problems may occur. This case demonstrates the potential for dissociation of a Morse taper between a modular femoral neck and stem.