Phenotype assessment for neurodegenerative murine models with ataxia and application to Niemann-Pick disease, type C1.

Identifying meaningful predictors of therapeutic efficacy from preclinical studies is challenging. However, clinical manifestations occurring in both patients and mammalian models offer significant translational value. Many neurological disorders, including inherited, metabolic Niemann-Pick disease, type C (NPC), exhibit ataxia.

Effects of early and later family violence on children's behavior problems and depression: a longitudinal, multi-informant perspective.

Objectives: To examine the effects of different forms of family violence at two developmental stages by assessing a sample of 110 Israeli children, drawn from the case files of Israeli family service agencies, studied longitudinally in both middle childhood and adolescence.

Methods: Information about the children's adjustment was obtained from parents, teachers, and the children themselves when the children averaged 10.6 and 15.

Adolescents' perceptions of attachments to their mothers and fathers in families with histories of domestic violence: a longitudinal perspective.

Objective: The effects of both childhood and teenage experiences of domestic violence on adolescent-parent attachments were examined.

Method: Israeli adolescents (M = 15.9 years) who were either victims of physical abuse, witnesses of physical spouse abuse, victims and witnesses of abuse, or neither victims nor witnesses of abuse were questioned about attachments to their parents using the Inventory of Parent and Peer Attachment [IPPA; Armsden, G.