Publications by authors named "Craig A Banotai"
J Biol Chem
September 2007
Article Synopsis
- MMP13 is a zinc-dependent protease responsible for breaking down type II collagen in cartilage, making it a key target in treating osteoarthritis.
- Previous MMP inhibitors caused painful musculoskeletal side effects due to their non-selectivity, but new inhibitors developed by researchers are designed to selectively target MMP13 without affecting other proteins.
- These new MMP13 inhibitors have shown promise in reducing cartilage damage in animal models without causing negative side effects, potentially leading to safer and more effective osteoarthritis treatments.
