Humans routinely make inferences about both the contents and the workings of other minds based on observed actions. People consider what others want or know, but also how intelligent, rational, or attentive they might be. Here, we introduce a new methodology for quantitatively studying the mechanisms people use to attribute intelligence to others based on their behavior.
View Article and Find Full Text PDFSummit Lake, Nevada (USA) is the last high-desert terminal lake to have a native self-sustaining population of threatened Lahontan cutthroat trout (Oncorhynchus clarkii henshawi). From spring 2015 to fall 2017, we quantified adult abundance and survival and the total annual spawning run. Abundance and survival were estimated with mark-recapture using PIT tags, and the annual spawning run was estimated with PIT tag detections and counts of spawners.
View Article and Find Full Text PDFThe application of oil-based leather dressing, while once considered a best practice in libraries, led to undesirable long-term consequences for bound materials. At the National Institutes of Health (NIH) in the National Library of Medicine (NLM), many leather-bound volumes had multiple applications of a mixture of neatsfoot oil and lanolin dressings liberally applied. The oils not only absorbed into the leather bindings but also migrated onto the pastedowns, end sheets, gutters, and text blocks.
View Article and Find Full Text PDFThis investigation sought to examine the contributions of exercise and nutrient replenishment on in vivo regulation of the insulin-like growth factor-I (IGF-I) axis components. Eight college-aged males completed three high-intensity interval training (HIIT) protocols followed by three post-exercise nutritional protocols: (1) placebo (EX); (2) carbohydrate only (CHO); and (3) essential amino acid/carbohydrate (EAA/CHO). Samples were analyzed for growth hormone (GH), free IGF-I, IGFBP-1, IGFBP-2, insulin, hematocrit, hemoglobin, serum leucine, matrix metalloproteinase-9 (MMP-9) proteolytic activity, and presence of IGFBP-3 protease activity.
View Article and Find Full Text PDFQuadratic aberration is successfully corrected with a segmented microelectromechanical deformable mirror in conjunction with a refractive lenslet array. Use of the lenslet array greatly improves the effective fill factor of the correcting element. Experimental results show correction approaching the diffraction limit for an extreme spherical aberration.
View Article and Find Full Text PDFThe range of enzyme applications has grown considerably in the last 10 years and new techniques are required to discover and evaluate the future areas of use. A number of different aspects of enzyme application are evaluated and consideration given as to how we may develop these new areas.
View Article and Find Full Text PDFAction-compatible blindness refers to the finding that target stimuli are perceived less frequently if they are presented during the planning or execution of a compatible action (e.g., a left arrow presented during a left manual key press) than during an incompatible action (Müsseler & Hommel, 1997 a, b).
View Article and Find Full Text PDFMost of the major psychiatric disorders have been analyzed at each of several different levels. For example, at the broadest level, epidemiological studies have served to establish the incidence of disorders like schizophrenia and major depression in a number of different populations. Family and twin studies have been important in determining the heritability of certain mental illnesses, and chromosomal and linkage analyses have identified a number of discrete loci that appear to be implicated in disease susceptibility or, even directly, in the pathogenesis of some disorders.
View Article and Find Full Text PDFThere has been substantial evidence for more than three decades that the major psychiatric illnesses such as schizophrenia, bipolar disorder, autism, and alcoholism have a strong genetic basis. During the past 15 years considerable effort has been expended in trying to establish the genetic loci associated with susceptibility to these and other mental disorders using principally linkage analysis. Despite this, only a handful of specific genes have been identified, and it is now generally recognized that further advances along these lines will require the analysis of literally hundreds of affected individuals and their families.
View Article and Find Full Text PDFWe report the results of a technique designed to measure interactions between different visual search processes. We interrupted pop-out search before it produced a detection response, by adding extra distractors to the display so that a target initially defined by a single feature difference (e.g.
View Article and Find Full Text PDFAnnu Rev Neurosci
September 2001
The announcement in October 1986 that the Nobel Prize for physiology or medicine was to be awarded to Rita Levi-Montalcini and Stanley Cohen for the discoveries of NGF and EGF, respectively, caused many to wonder why Viktor Hamburger (in whose laboratory the initial work was done) had not been included in the award. Now that the dust has settled, the time seems opportune to reconsider the antecedent studies on the relation of the developing nervous system to the peripheral structures it innervates. The studies undertaken primarily to investigate this issue culminated in the late 1950s in the discovery that certain tissues produce a nerve growth-promoting factor that is essential for the survival and maintenance of spinal (sensory) ganglion cells and sympathetic neurons.
View Article and Find Full Text PDFNeurological and psychiatric illnesses are among the most common and most serious health problems in developed societies. The most promising advances in neurological and psychiatric diseases will require advances in neuroscience for their elucidation, prevention, and treatment. Technical advances have improved methods for identifying brain regions involved during various types of cognitive activity, for tracing connections between parts of the brain, for visualizing individual neurons in living brain preparations, for recording the activities of neurons, and for studying the activity of single-ion channels and the receptors for various neurotransmitters.
View Article and Find Full Text PDFWe interrupted pop-out search before it produced a detection response by adding extra distractors to the search display. We show that when pop-out for an orientation target fails because of this interruption, it nevertheless provides useful information to the processes responsible for difficult search. That is, partial pop-out assists difficult search.
View Article and Find Full Text PDFVisual perception consists of early preattentive processing and subsequent attention-demanding processing. Most researchers implicitly treat preattentive processing as a domain-dependent, indivisible stage. We show, however, by interrupting preattentive visual processing of color before its completion, that it can be dissected both temporally and spatially.
View Article and Find Full Text PDFAnnu Rev Neurosci
September 2000
One of the most significant developments in biology in the past half century was the emergence, in the late 1950s and early 1960s, of neuroscience as a distinct discipline. We review here factors that led to the convergence into a common discipline of the traditional fields of neurophysiology, neuroanatomy, neurochemistry, and behavior, and we emphasize the seminal roles played by David McKenzie Rioch, Francis O Schmitt, and especially Stephen W Kuffler in creating neuroscience as we now know it. The application of the techniques of molecular and cellular biology to the study of the nervous system has greatly accelerated our understanding of the mechanisms involved in neuronal signaling, neural development, and the function of the major sensory and motor systems of the brain.
View Article and Find Full Text PDFJ Clin Pathol
February 2000
Aim: To define the biological nature and malignant potential of interval cancers presenting to a breast unit within the NHS breast screening programme.
Methods: 112 interval cancers were compared with matched, screen detected and symptomatic cancers in terms of their radiographic, histopathological, and immunohistochemical features.
Results: Interval cancers, strictly defined, showed no characteristic radiographic pattern.
Olds, Cowan and Jolicoeur [2000. Tracking visual search over space and time. Psychonomic Bulletin & Review (in press)] interrupted pop-out search by adding distractors to a display after a delay.
View Article and Find Full Text PDFBackground: The present study was undertaken to investigate the effect of denervation on leukocyte function in soft-tissue infection in an isolated in vivo ovine flap model.
Methods: Fifteen adult ewes were divided into three groups. An island pedicle flap was raised on the right buttock.
Visual attention can be goal driven, stimulus driven, or a combination of the two. Here we report evidence for an unexpectedly stimulus-driven component of visual search for a target defined by color. Observers demonstrated a surprisingly cost-free ability to incorporate multiple classifiers in search for a target of one color from among distractors of other colors.
View Article and Find Full Text PDFVisual search for a colour target in distractors of two other colours is dramatically affected by the configuration of the colours in CIE (x, y) space. To a first approximation, search is difficult when a target's chromaticity falls directly between (i.e.
View Article and Find Full Text PDFPercept Psychophys
August 1998
Bauer, Jolicoeur, and Cowan (1996b, 1996c) demonstrated difficult visual search for color targets that were not linearly separable (in color space) from two distractor colors and easier search for linearly separable targets. This suggested that search is mediated by a chromatically linear discrimination mechanism (see D'Zmura, 1991). However, in those experiments, the targets that were not linearly separable fell midway between the distractor colors and thus corresponded to the admix of the distractor colors.
View Article and Find Full Text PDFTraditional and immunohistochemical markers of prognosis were examined in 455 mammary carcinomas derived from breast cancer screening and compared with those of 277 carcinomas presenting symptomatically over the same period. Tumours detected by population screening under the U.K.
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