A comparison of visual and molecular methods for inferring biological communities in aquaculture enriched sediments - Impact assessment and cost-benefit analysis.

Nutrients introduced to the environment by finfish aquaculture pose environmental risks, which can be mitigated by robust environmental monitoring. Biological communities in soft sediments are good indicators of aquaculture derived environmental changes. Traditionally, monitoring programs have visually surveyed macrofauna communities.

Myosin Vb Traffics P-Glycoprotein to the Apical Membrane of Intestinal Epithelial Cells.

Background & Aims: The xenobiotic efflux pump P-glycoprotein is highly expressed on the apical membrane of the gastrointestinal tract, where it regulates the levels of intracellular substrates. P-glycoprotein is altered in disease, but the mechanisms that regulate the levels of P-glycoprotein are still being explored. The molecular motor myosin Vb (Myo5b) traffics diverse cargo to the apical membrane of intestinal epithelial cells.

Adipocyte deletion of the oxygen-sensor PHD2 sustains elevated energy expenditure at thermoneutrality.

Enhancing thermogenic brown adipose tissue (BAT) function is a promising therapeutic strategy for metabolic disease. However, predominantly thermoneutral modern human living conditions deactivate BAT. We demonstrate that selective adipocyte deficiency of the oxygen-sensor HIF-prolyl hydroxylase (PHD2) gene overcomes BAT dormancy at thermoneutrality.

How Do Young Soccer Players Train? A 5-Year Analysis of Weekly Training Load and its Variability Between Age Groups in an Elite Youth Academy.

Connolly, DR, Stolp, S, Gualtieri, A, Ferrari Bravo, D, Sassi, R, Rampinini, E, and Coutts, AJ. How do young soccer players train? A 5-year analysis of weekly training load and its variability between age groups in an elite youth academy. J Strength Cond Res 38(8): e423-e429, 2024-The aim of this study was to quantify the session rating of perceived exertion (sRPE), duration, and training load accrued across typical training weeks undertaken by youth soccer players.

Solving the High-Intensity Multimodal Training Prescription Puzzle: A Systematic Mapping Review.

Background: High-Intensity Multimodal Training (HIMT) refers to all styles of high-intensity combined aerobic, resistance and/or bodyweight exercise. Previous heterogeneity in exercise prescription and reporting in HIMT reduces the understanding of which factors should be considered when prescribing HIMT (e.g.

The physical, technical and tactical demands of on-field training drills in professional Rugby league: a systematic scoping review.

Objectives: The main objectives of this scoping review were to conduct a systematic search on the physical, technical and tactical demands of rugby league training, consolidate and summarise key findings and identify any existing gaps in knowledge.

Methods: A systematic online search of Scopus, PubMed, MEDLINE and SPORTDiscus was conducted from earliest record to 6 August 2023 and supplemented by manually searching reference lists. The Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) Checklist was followed.

External Load Fluctuations Across an Amateur Athletic Union Basketball Season.

Kutson, CW, Russell, JL, Strack, D, Coutts, AJ, and McLean, BD. External load fluctuations across an Amateur Athletic Union basketball season. J Strength Cond Res 38(3): 592-598, 2024-Amateur Athletic Union (AAU) competitions are an important component of the developmental pathway for youth basketball athletes.

The Relationship Between Mental Fatigue and Shooting Performance Over the Course of a National Collegiate Athletic Association Division I Basketball Season.

Daub, BD, McLean, BD, Heishman, AD, Peak, KM, and Coutts, AJ. The relationship between mental fatigue and shooting performance over the course of a National Collegiate Athletic Association Division I basketball season. J Strength Cond Res 38(2): 334-341, 2024-The aim of this investigation was to examine the presence of mental fatigue and concurrent changes in shooting performance across various experimental weeks throughout a National Collegiate Athletic Association (NCAA) basketball season.

Exploring subjective responses in high-intensity multimodal training: an online cross-sectional survey.

Objectives: The purpose of this study was to investigate exercise enjoyment in high-intensity multimodal training (HIMT) in current and previous HIMT participants and identify factors associated with HIMT that mediate exercise enjoyment and motivation.

Design And Setting: A 124-item web-based survey was distributed to a cross-sectional voluntary convenience sample from August to the end of September 2021.

Participants: Global current and previous HIMT participants.

Core Body Temperatures in Intermittent Sports: A Systematic Review.

Background: Hyperthermia (and associated health and performance implications) can be a significant problem for athletes and teams involved in intermittent sports. Quantifying the highest thermal strain (i.e.

Evaluating a Photogrammetry-Based Video for Undergraduate Anatomy Education.

Modern anatomy education has benefitted from the development of a wide range of digital 3D resources in the past decades, but the impact of the COVID-19 pandemic has sparked an additional demand for high-quality online learning resources. Photogrammetry provides a low-cost technique for departments to create their own photo-realistic 3D models of cadaveric specimens. However, to ensure accessibility, the design of the resulting learning resources should be carefully considered.

Combining nonsense mutation suppression therapy with nonsense-mediated decay inhibition in neurofibromatosis type 1.

Neurofibromatosis type 1 (NF1) results from germline mutations in the tumor-suppressor gene and predisposes patients to developing nervous system tumors. Twenty percent of NF1 patients harbor nonsense mutations resulting in premature termination codons (PTCs). Nonsense suppression therapies can facilitate ribosomal readthrough of PTCs to restore full-length protein, but their potential in NF1 is underexplored.

Sensitivity of Countermovement Jump Variables in Professional Rugby Union Players Within a Playing Season.

Howarth, DJ, McLean, BD, Cohen, DD, and Coutts, AJ. Sensitivity of countermovement jump variables in professional rugby union players within a playing season. J Strength Cond Res 37(7): 1463-1469, 2023-The aim of this study was to explore the measurement sensitivity of a wide range of countermovement jump (CMJ) variables to a full European professional rugby union season.

p53-dependent DNA repair during the DNA damage response requires actin nucleation by JMY.

The tumour suppressor p53 is a nuclear transcription factor with key roles during DNA damage to enable a variety of cellular responses including cell cycle arrest, apoptosis and DNA repair. JMY is an actin nucleator and DNA damage-responsive protein whose sub-cellular localisation is responsive to stress and during DNA damage JMY undergoes nuclear accumulation. To gain an understanding of the wider role for nuclear JMY in transcriptional regulation, we performed transcriptomics to identify JMY-mediated changes in gene expression during the DNA damage response.

Understanding Training Load as Exposure and Dose.

Various terms used in sport and exercise science, and medicine, are derived from other fields such as epidemiology, pharmacology and causal inference. Conceptual and nomological frameworks have described training load as a multidimensional construct manifested by two causally related subdimensions: external and internal training load. In this article, we explain how the concepts of training load and its subdimensions can be aligned to classifications used in occupational medicine and epidemiology, where exposure can also be differentiated into external and internal dose.

Development and Validation of Single Items for Fatigue and Recovery in Dancers.

Purpose: To examine the construct validity and reliability of 2 single items for fatigue and recovery in dancers. The construct validity was assessed using reference instruments: the fatigue items of the Brunel Mood Scale (BRUMS) and the Short Recovery and Stress Scale (SRSS). A secondary aim was to explore the respondent interpretation of these 2 items using a concept identification approach.

Finding the Signal in the Noise-Interday Reliability and Seasonal Sensitivity of 84 Countermovement Jump Variables in Professional Basketball Players.

Mercer, RAJ, Russell, JL, McGuigan, LC, Coutts, AJ, Strack, DS, and McLean, BD. Finding the signal in the noise-interday reliability and seasonal sensitivity of 84 countermovement jump variables in professional basketball players. J Strength Cond Res 37(2): 394-402, 2023-This study examined the measurement characteristics of countermovement jump (CMJ) variables in basketball athletes using different variable selection criteria.

CRISPR/Cas9-editing of to generate pigs with hypogonadotropic hypogonadism as a castration free trait.

Most male pigs are surgically castrated to avoid puberty-derived boar taint and aggressiveness. However, this surgical intervention represents a welfare concern in swine production. Disrupting porcine is hypothesized to delay or abolish puberty by inducing variable hypogonadotropism and thus preventing the need for castration.

National survey of mental health and life satisfaction of gig workers: the role of loneliness and financial precarity.

Objectives: To compare the mental health and life satisfaction of those employed in the gig work and contingent work with those in full-time or part-time work and the unemployed in the UK during the COVID-19 pandemic. To explore the possible mechanisms of latent and manifest benefits of employment, such as financial precarity and loneliness.

Design: Cross-sectional survey.

Impacts of mental fatigue and sport specific film sessions on basketball shooting tasks.

Purpose: The aim of this investigation was to examine the impact of mental fatigue on basketball specific shooting performance, utilising the newly developed basketball Standardized Shooting Task (SST).

Methods: Fifteen male elite NCAA Division 1 collegiate basketball players (Age 20.2 ± 1.

Contextual Factors Influencing Physical Activity and Technical Performance in Australian Football League Women's Competition Match-Play.

Leabeater, A, Clarke, A, and Sullivan, C. Contextual factors influencing physical activity and technical performance in AFLW competition match-play. J Strength Cond Res 37(1): 194-199, 2023-The purpose of this study was to examine the influence of contextual factors on physical activity and technical match performance during Australian Football League Women's (AFLW) competition match-play.

Assessment of Physical, Technical, and Tactical Analysis in the Australian Football League: A Systematic Review.

Background: Elite Australian Football (AF) match-play requires proficiency in physical, technical, and tactical elements. However, when analysing player movement practitioners commonly exclude technical and tactical considerations, failing to recognise the multifactorial nature of AF match-play and providing little context into the movement requirements of the players.

Objectives: This systematic review aimed to identify the physical, technical, and tactical requirements of the Australian Football League (AFL) and to highlight the importance of integrating data from multiple sources when analysing player output.