Publications by authors named "Couto L"

Respiratory diseases pose a significant threat to the health of the Brazilian population, ranking among the leading causes of hospitalizations and deaths in the country. The most impacted demographics are children, adolescents, and older adults, who respectively have the highest rates of hospitalizations and deaths. An exploratory ecological study was conducted to assess the spatio-temporal distribution of hospitalizations and deaths due to respiratory diseases among children, adolescents, and older adults residing in municipalities in the Brazilian Legal Amazon.

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Objective: A growing number of U.S. states have legalized cannabis for people 21 and older, but cannabis use and misuse can negatively impact college students' health and academic achievements.

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Gastric cancer (GC) is one of the most common malignant tumors in the digestive system and due to its poor prognosis, there is an increase in the demand for more effective anticancer therapies. Interleukins are potential anticancer agents which can modulate expression of cancer related genes and have therapeutic effects. Interleukin 12 (IL-12) exhibits potent anti-tumor, anti-angiogenic and anti-metastatic activities and represents the ideal candidate for tumor immunotherapy, due to its ability to activate both innate and adaptive immunities.

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  • Tobacco use is common among patients with schizophrenia (SCHZ), and the study explores how the order of tobacco and SCHZ onset affects their relationship.
  • Using a mouse model, researchers tested the effects of either tobacco exposure before or after inducing SCHZ symptoms with phencyclidine (PCP), measuring behaviors linked to schizophrenia.
  • Results revealed that the sequence of exposure alters the impact on behaviors, suggesting that the order of tobacco use and SCHZ plays a crucial role in understanding their interaction and potential neurobiological mechanisms.*
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  • Trypanosoma vivax infections are prevalent in Africa and were introduced to Latin America in 1919, causing trypanosomosis, with some local cattle breeds (trypanotolerant) showing resilience against the disease.
  • A study evaluated the Curraleiro Pé-Duro (CPD) breed's ability to meet trypanotolerant criteria compared to Holstein/Gyr breeds by assessing their response to T. vivax infection over 532 days.
  • Results indicated that CPD animals maintained normal health without treatment and demonstrated recovery from anemia, while the Holstein/Gyr breed exhibited significant weight loss and required treatment after infection.
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  • The study assessed the effects of the tick Rhipicephalus microplus on Holstein calves' health and productivity on a tropical dairy farm, focusing on factors impacting tick fever (TF) outbreaks.
  • It involved tracking rectal temperatures and blood sampling of calves to diagnose TF agents like Anaplasma marginale and Babesia species, leading to specific treatment protocols.
  • Results indicated that factors like colostrum quality, embryo transfer status, and weaning weight affected the recurrence of TF, with each recurrence reducing first lactation milk production by over 200 liters.
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This study evaluated the reproductive, productive and financial consequences of chronic Trypanosoma vivax infection in a dairy cattle herd located in a region without the cyclic vector during two years. Animals were categorized as either positive (chronically infected) or negative for T. vivax antibodies using a commercial rapid test.

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  • The study assessed the impact of various supportive treatments on improving packed cell volume (PCV) in dairy calves infected with tick fever agents, following specific antibiotic treatments.
  • Five supportive products were tested on Girolando female calves, aged four to six months, which were naturally infected and infested with R. microplus, with evaluations made on days 0, 3, and 7 post-treatment.
  • Results indicated that while oral or intravenous vitamins and minerals improved PCV, certain tonics showed no positive effects, and only Type III iron injections significantly raised hemoglobin and PCV levels, highlighting the need for further research on iron supplementation methods.
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This experiment compared narasin and monensin as anticoccidials for calves naturally infected with spp. Twenty-four weaned, non-castrated male calves ( ×  cross) were assigned to this experiment (days -8 to 42). All calves were infected by spp.

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  • This study investigated chronic sclerosing sialadenitis (CSS) to explore its histopathological and immunohistochemical features, with a focus on IgG4-related disease (IgG4-RD).
  • Out of 17 cases examined, the majority showed inflammatory and fibrotic changes, with notable presence of CD3-positive T lymphocytes and stromal fibroblasts, but only three cases met IgG4-RD criteria.
  • The findings suggest that CSS in the submandibular gland is primarily a reactive condition rather than directly related to IgG4-RD, providing valuable insights into its characteristics and immunological profile.
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This study aimed to investigate seven outbreaks of A. marginale infection in two regions of Brazil, affecting taurine, zebu, and crossbred cattle. We assessed the possible causes, treatment measures, and genetic diversity of A.

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Background: In 2022, fluralaner was launched on the market for use in the control of the cattle tick Rhipicephalus microplus after showing 100% efficacy in registration trials against the causative agents of cattle tick fever (TFAs). The aim of the present study was to determine whether a strategic control regimen against R. microplus using fluralaner (FLU) in Holstein calves grazing in a tropical region would alter the enzootic stability status of cattle tick fever, triggering outbreaks in these animals up to 22 months age.

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This work investigated the mechanical transmission of Trypanosoma vivax by Stomoxys calcitrans to cattle in a region without a cyclic vector. The study involved two experiments, one with calves experimentally infected with T. vivax, in the acute phase of trypanosomosis (Experiment 1) and the other in the chronic phase (Experiment 2).

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The present work evaluated the pharmacokinetics and efficacy of the association of 15cmg/kg toltrazuril +5cmg/kg fenbendazole against Eimeria spp. and gastrointestinal nematodes (GINs) in calves of different regions of Brazil (Center-West, Southeast, and South). A total of seven experiments were carried out, five of which determined formulation efficacy against Eimeria spp.

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  • Musca domestica, commonly known as the housefly, is significant in various fields such as health, veterinary, and forensic science due to its ability to spread diseases and infestations.
  • The study focuses on characterizing the external structures of housefly pupae under different temperatures and humidity levels to understand their developmental stages better.
  • Findings from the experiment reveal the timing of different developmental stages and morphological changes, which can help forensic entomologists estimate the time of death in criminal investigations.
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Purpose: The role of marks in the University Admission Test (UAT) plus the marks from pre-university academic records in predicting academic achievement at the end of the Medicine undergraduate degree program is not completely known. This study was undertaken to compare the performance of marks in the UAT alone with those of the UAT plus marks from the National High School Exam (ENEM in Brazil) regarding students' outcomes at the end of the Medicine undergraduate degree program.

Methods: Fifty-one (51) students from the last semester (12th) of our Medicine undergraduate degree program were included in the study.

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Objective: This study aims to assess covid-19 morbidity, mortality, and severity from 2020 to 2021 in five Brazilian Amazon states with the highest records of wildfires.

Methods: A distributed lag non-linear model was applied to estimate the potential exposure risk association with particulate matter smaller than 2.5-µm in diameter (PM2.

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Fitspiration content on Instagram often includes images in which women are objectified but may also include captions that aim to positively motivate viewers, such as through messaging about body appreciation. Viewing objectifying content in fitspiration posts may be problematic for young women's mental health, but it's unclear if positive messaging may help to alleviate some of these effects. In this study, we conducted a 2 × 2 online experiment assessing the effects of body appreciation and objectification content present in Instagram fitness posts by influencers on young women ( = 200).

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Chemoprophylaxis with dipropionate imidocarb (IMD) is a method adopted to prevent cattle tick fever (TF). Sixty weaned dairy heifers (±60 days old), without previous exposure to Rhipicephalus microplus ticks, were housed in Tifton paddocks and were subsequently exposed to R. microplus ticks and monitored up to 315 days old.

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This paper presents an innovative and efficient methodology for the determination of the solid-state diffusion coefficient in electrode materials with phase transitions for which the assumption of applying the well-known formula from the work of Weppner et al. is not satisfied. This methodology includes a k-means machine learning screening of Galvanostatic Intermittent Titration Technique (GITT) steps, whose outcomes feed a physics-informed algorithm, the latter involving a pseudo-two-dimensional (P2D) electrochemical model for carrying out the numerical simulations.

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Sexual assault is a serious public health issue that is particularly pervasive on U.S. college campuses, and it is well established that men's acceptance of rape myths is associated with negative, and even harmful, attitudes and behaviors toward women.

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