Nanoporous gold nanoleaf as tunable metamaterial.

We have studied optical properties of single-layer and multi-fold nanoporous gold leaf (NPGL) metamaterials and observed highly unusual transmission spectra composed of two well-resolved peaks. We explain this phenomenon in terms of a surface plasmon absorption band positioned on the top of a broader transmission band, the latter being characteristic of both homogeneous "solid" and inhomogeneous "diluted" Au films. The transmission spectra of NPGL metamaterials were shown to be controlled by external dielectric environments, e.

The prescription opioid and heroin crisis: a public health approach to an epidemic of addiction.

Public health authorities have described, with growing alarm, an unprecedented increase in morbidity and mortality associated with use of opioid pain relievers (OPRs). Efforts to address the opioid crisis have focused mainly on reducing nonmedical OPR use. Too often overlooked, however, is the need for preventing and treating opioid addiction, which occurs in both medical and nonmedical OPR users.

Addiction and the science of history.

Aims: To discuss the contributions historians have made to the addiction field, broadly construed to include licit and illicit drug use, drug policy, drug treatment and epidemiological and neuroscientific research.

Methods: Review of literature, highlighting specific contributions and controversies from recent research on the United States, the United Kingdom, China and world history.

Findings And Conclusions: At the bar of addiction knowledge, historians make for excellent companions--until they turn quarrelsome.

Gender imbalances in history: causes, consequences and social adjustment.

This article surveys the causes, consequences and social adjustments of gender-imbalanced populations. Though recent studies emphasize the role of medical technology in creating gender imbalances, historical and biological evidence shows that they have deeper and more tangled roots. Female-selective abortion, sperm sorting and other innovations are essentially new wrinkles in a very old social problem.

Mr. ATOD's wild ride: what do alcohol, tobacco, and other drugs have in common?

All researchers agree that individuals can become intoxicated by and dependent on alcohol, tobacco, and other psychoactive drugs. But they have disagreed over whether, and to what extent, drug pathologies comprise a unitary medical problem. Most critically, does addiction have a biological common denominator? Consensus on this question has shifted back and forth.

The Controlled Substances Act: how a "big tent" reform became a punitive drug law.

The 1970 Controlled Substances Act was part of an omnibus reform package designed to rationalize, and in some respects to liberalize, American drug policy. While the legislation provided additional resources for law enforcement and a systematic means for regulating the use of most psychoactive drugs, it also did away with mandatory minimum sentences and provided more support for treatment and research. Over the next three decades, and in response to public alarm about drug abuse, the US Congress continuously amended the law to produce a more punitive system of drug control.

The prepared mind: Marie Nyswander, methadone maintenance, and the metabolic theory of addiction.

Marie Nyswander was the co-discoverer of methadone maintenance. In the 1960s she and Vincent Dole carried out clinical trials and established the first officially sanctioned methadone clinics, which became models for maintenance programs throughout the world. In 1967 she and Dole theorized that heroin addicts had undergone a permanent metabolic change.