Publications by authors named "Courtney Sniffen"
Article Synopsis
- Mitotic exit in budding yeast is essential for maintaining genome integrity and involves cyclin B destruction and proper nuclear positioning.
- The mitotic exit network (MEN) activates during anaphase through the association of the Dbf2-Mob1 kinase complex with the Nud1 scaffold protein at spindle pole bodies (SPBs).
- A newly identified hyperactive allele of Cdc15 allows its recruitment to SPBs throughout the cell cycle, disrupting the normal coupling between nuclear position and mitotic exit in cells with mispositioned spindles, emphasizing the role of scaffold regulation in signaling pathways.
Chromosome gains and losses are a frequent feature of human cancers. However, how these aberrations can outweigh the detrimental effects of aneuploidy remains unclear. An initial comparison of existing chromosomal instability (CIN) mouse models suggests that aneuploidy accumulates to low levels in these animals.
View Article and Find Full Text PDFThe proper regulation of cell cycle transitions is paramount to the maintenance of cellular genome integrity. In , the mitotic exit network (MEN) is a Ras-like signaling cascade that effects the transition from M phase to G1 during the cell division cycle in budding yeast. MEN activation is tightly regulated.
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