In vitro effects of the active metabolite of leflunomide, A77 1726, on feline herpesvirus-1.

Objective: To determine whether the active metabolite of leflunomide, A77 1726 (A77), inhibits replication of feline herpesvirus-1 (FHV-1) in cell culture.

Study Population: Crandell Rees feline kidney (CRFK) cell cultures.

Procedures: Cell cultures were inoculated with FHV-1 and treated simultaneously with concentrations of A77 ranging from 0 to 200microM.