Clinical inquiries. Do intercontraction intervals predict when a woman at term should seek evaluation of labor?

Intercontraction intervals do not predict when a woman at term should seek evaluation of labor. However, a reduction in the intercontraction interval is associated with active labor. Most primigravidas who have had regular contractions for 2 hours and multigravidas who have had regular contractions for 1 hour have not transitioned into the active phase of labor.

Brain volume in first-episode schizophrenia: systematic review and meta-analysis of magnetic resonance imaging studies.

Background: Studies of people with schizophrenia assessed using magnetic resonance imaging (MRI) usually include patients with first-episode and chronic disease, yet brain abnormalities may be limited to those with chronic schizophrenia.

Aims: To determine whether patients with a first episode of schizophrenia have characteristic brain abnormalities.

Method: Systematic review and meta-analysis of 66 papers comparing brain volume in patients with a first psychotic episode with volume in healthy controls.