Patterns of alcohol use among middle school students in rural communities: Associations with community violence exposure.

Stress-coping theory posits that exposure to stressors, such as community violence, increases risk for early alcohol initiation. The current study identified patterns of alcohol use in an ethnically diverse sample of early adolescents in rural communities, and examined relations between different forms of exposure to community violence and severity of adolescents' alcohol use patterns. Participants were 5011 middle school students (46.

Beliefs as Mediators of Relations Between Exposure to Violence and Physical Aggression During Early Adolescence.

This study examined beliefs about aggression and self-efficacy for nonviolent responses as mediators of longitudinal relations between exposure to violence and physical aggression. Participants were a predominantly African American (79%) sample of 2,705 early adolescents from three middle schools within urban neighborhoods with high rates of violence. Participants completed measures across four waves (fall, winter, spring, and summer) within a school year.

Early Adolescents' Social Goals in Peer Conflict Situations: A Mixed Methods Study.

Identification of goals is a key social-cognitive process that guides whether adolescents engage in aggressive or nonviolent behavior during social conflicts. This study investigated early adolescents' goals in response to hypothetical social conflict situations involving close friends and peers. Participants ( = 160; = 12.

Patterns of Adolescents' Appraisals of Responses to Problem Situations: Associations with Aggression, Victimization, and Contextual Factors.

Although considerable research has examined factors that influence social-cognitive processes related to aggression, few studies have examined the factors that influence adolescents' appraisal of the effectiveness of responses, particularly nonviolent alternatives to aggression. This study addressed that gap by examining patterns of adolescents' perceived effectiveness of nonviolent and aggressive responses to hypothetical problem situations and their relations with aggression, victimization, and individual and contextual risk factors. The participants were a predominantly African American (90%) sample of 1469 students (55% female; mean age = 12.

The Model for Understanding Inpatient Aggression: A Version for Mental Health Nurses Working in Prisons.

Preventing and managing aggression remains an important and challenging task for mental health nurses. Despite the concern, there is a dearth of frameworks to assist practice and inform assessment and intervention related to aggression, for forensic mental health nurses working in prisons. This paper presents a model for understanding aggression within prison mental health units.

A Meta-Analysis Linking Parent-to-Child Aggression and Dating Abuse During Adolescence and Young Adulthood.

Relationship continuity and social learning theories provide support for parent-to-child aggression as one potential explanatory factor for dating abuse (DA); however, empirical results are mixed across studies as to the strength of this association. This meta-analysis sought to estimate the overall size of this effect among adolescent and young adult samples and investigate potential moderating factors including sample and measurement variables. Records were identified using a computerized search of databases with several keywords.

A pilot study for evaluation of hypotonia in children with neurofibromatosis type 1.

There are currently no objective criteria to evaluate pediatric hypotonia. The purpose of this pilot study was to identify diagnostic criteria for assessing hypotonia in children with neurofibromatosis type 1. Fifty-five subjects between the ages of 1 and 7 years with a diagnosis of neurofibromatosis type 1 were evaluated.

Central respiratory failure during acute organophosphate poisoning.

Organophosphate (OP) pesticide poisoning is a global health problem with over 250,000 deaths per year. OPs affect neuronal signaling through acetylcholine (Ach) neurotransmission via inhibition of acetylcholinesterase (AChE), leading to accumulation of Ach at the synaptic cleft and excessive stimulation at post-synaptic receptors. Mortality due to OP agents is attributed to respiratory dysfunction, including central apnea.

Dichlorvos exposure to the Kölliker-fuse nuclei is sufficient but not necessary for OP induced apnea.

Patients exposed to organophosphate (OP) compounds demonstrate a central apnea. The Kölliker-fuse nuclei (KF) are cholinergic nuclei in the brainstem involved in central respiratory control. We hypothesize that exposure of the KF is both necessary and sufficient for OP induced central apnea.

Longitudinal analysis of developmental delays in children with neurofibromatosis type 1.

Children with neurofibromatosis type 1 exhibit a variety of developmental delays. However, there is little information about the progression of these deficits over the course of development. Using the Parents' Evaluation of Developmental Status measurement tool, we assessed 124 infants (0-2 years of age), preschool-age children (3-5 years of age), and school-age children (6-8 years of age) with neurofibromatosis type 1 to define the natural history of delays.

The association between hypotonia and brain tumors in children with neurofibromatosis type 1.

Children with the neurofibromatosis type 1 (NF1) inherited tumor predisposition syndrome are at risk for the development of brain tumors. In addition, children with neurofibromatosis type 1 often exhibit low tone (hypotonia). In this study, the authors explored the hypothesis that hypotonia could be a clinical indicator of glioma in children with neurofibromatosis type 1.

Intralipid fat emulsion decreases respiratory failure in a rat model of parathion exposure.

Background: Therapies exist for acute organophosphate (OP) exposure but mortality rates remain high (10% to 20%). Currently, treatment focuses on reversing the resultant cholinergic excess effects through the use of atropine. Intralipid fat emulsion (IFE) has been used to treat lipophilic drug ingestions and theoretically would be beneficial for some OP agents.

Developmental delays in children with neurofibromatosis type 1.

It is well documented that children with neurofibromatosis type 1 are at high risk for a variety of cognitive and learning deficits. The current study investigated the use of a developmental screening tool, the Parents' Evaluation of Developmental Status: Developmental Milestones, as an accurate, reliable, and efficient indicator of developmental delays. Sixty-eight percent of children with neurofibromatosis type 1 were found to have a developmental delay in at least 1 of the 8 areas tested by the Parents' Evaluation of Developmental Status: Developmental Milestones.

BMP gene delivery for alveolar bone engineering at dental implant defects.

A challenge in the tissue engineering of alveolar bone surrounding oral or dental implants is achieving the targeted and sustained delivery of growth-promoting molecules at the osteotomy site. Bone morphogenetic protein-7 (BMP-7) has demonstrated the ability to stimulate bone regeneration in multiple skeletal sites, including the craniofacial complex. This study evaluates in vivo gene delivery of BMP-7 for bone tissue engineering around titanium dental implants.