Publications by authors named "Courtney Dinardo"
Delayed hemolytic transfusion reaction (DHTR) poses a significant challenge in patients receiving blood transfusions. This case report highlights the complexities of managing DHTR in a newly diagnosed chronic myelomonocytic leukemia (CMML) patient with clinically significant JKa and little c antibodies during induction chemotherapy. A 46-year-old woman with CMML-2 who presented for induction chemotherapy was found to have hemolytic anemia.
View Article and Find Full Text PDFPatients with newly diagnosed acute myeloid leukemia (ND-AML) derive variable survival benefit from venetoclax + hypomethylating agent (Ven-HMA) therapy. The primary objective in the current study was to develop genetic risk models that are predictive of survival and are applicable at the time of diagnosis and after establishing treatment response. Among 400 ND-AML patients treated with Ven-HMA at the Mayo Clinic, 247 (62%) achieved complete remission with (CR) or without (CRi) count recovery.
View Article and Find Full Text PDFArticle Synopsis
Mutation- and MRD-informed treatments for transplant-ineligible patients.
Hematology Am Soc Hematol Educ Program
December 2024
Article Synopsis
Article Synopsis
The outcomes of patients with acute myeloid leukemia (AML) and bone marrow fibrosis (MF) are not well defined. The study objectives were to evaluate the degrees of MF in AML, and corresponding response rates and outcomes. We performed a retrospective review of 2302 patients with AML.
View Article and Find Full Text PDFArticle Synopsis
- * The study reveals that RAS mutations transform specific blood cell progenitors (granulocyte-monocyte progenitors) that have already acquired other mutations, suggesting advanced leukemia can arise from different cell types than initial clones.
- * RAS-mutant leukemia stem cells show resistance to the treatment drug venetoclax due to changes in gene expression, leading to worse treatment responses and relapses characterized by monocytic features, highlighting the impact of genetic drivers on therapy effectiveness.
Article Synopsis
Malignancies are reliant on glutamine as an energy source and a facilitator of aberrant DNA methylation. We demonstrate preclinical synergy of telaglenastat (CB-839), a selective glutaminase inhibitor, combined with azacytidine (AZA), followed by a single-arm, open-label, phase 1b/2 study in persons with advanced myelodysplastic syndrome (MDS). The dual primary endpoints evaluated clinical activity, safety and tolerability; secondary endpoints evaluated pharmacokinetics, pharmacodynamics, overall survival, event-free survival and duration of response.
View Article and Find Full Text PDFArticle Synopsis
- Advances in understanding the molecular pathobiology of acute myeloid leukemia (AML) have led to the development of twelve new targeted therapies approved since 2017, including various inhibitors and antibody-drug conjugates.
- These therapies, such as venetoclax and FLT3 inhibitors, aim to treat specific AML subsets and improve patient outcomes through precision medicine.
- Successful treatment of AML requires specialized expertise, access to diverse therapies, and a strong supportive care system, alongside ongoing research into new treatment options and combinations.
Background: FLT3-ITD AML is associated with an increased risk of relapse, leading many patients to receive an allogeneic hematopoietic stem cell transplantation (alloHCT) after induction. Unfortunately, relapse rate after alloHCT remains high and strategies are needed to improve outcomes.
Materials And Methods: We performed a retrospective analysis of adult patients with FLT3-ITD AML who received alloHCT from 6/1/2016 to 12/31/2020 and received gilteritinib (GILT) or sorafenib (SORA)as post-transplant maintenance, outside of a clinical trial.
Article Synopsis
- Aberrant expression of HOX and MEIS1 family genes in certain leukemias disrupts normal blood cell differentiation and contributes to leukemia development.
- Menin inhibitors can target the interaction between KMT2A and menin, reducing the abnormal expression of key factors and promoting differentiation in these leukemias.
- A collaborative effort among pediatric and adult specialists aims to advance menin inhibitors in treatment, offering a comprehensive overview of clinical trials and advocating for inclusive trial designs for youth.
Article Synopsis
- The European LeukemiaNet (ELN) previously created genetic risk classifications using data from younger adults who underwent intensive chemotherapy.
- New research has emerged analyzing patients who receive less-intensive therapies, highlighting the need for tailored classifications.
- This has led to a proposal for a new ELN genetic risk classification specifically designed for patients undergoing these alternative treatment options.