Framework for fiscal impact analysis of managing initial caries lesions with noninvasive therapies.

Background: Evidence-based noninvasive caries therapies for initial caries lesions are available in the United States. Fundamental differences between noninvasive therapies and the traditional surgical dental approach warrant a study of the financial scalability.

Methods: The financial costs and benefits of fee-for-service clinics and payors were compared across 11 scenarios simulating the treatment of 1,000 initial caries lesions during a 3-year period.

Systematic review and meta-analysis on the effect of self-assembling peptide P-4 on arrest, cavitation, and progression of initial caries lesions.

Background: Simple noninvasive evidence-based interventions for caries are needed to overcome limitations in the restorative paradigm. The self-assembling peptide P-4 is a noninvasive intervention that regenerates enamel in initial caries lesions.

Studies Reviewed: The authors conducted a systematic review and meta-analysis on the effectiveness of the P-4 products Curodont Repair (Credentis; now manufactured by vVARDIS) (CR) and Curodont Repair Fluoride Plus (Credentis; now manufactured by vVARDIS) on initial caries lesions.

Perforant Path Fiber Loss Results in Mnemonic Discrimination Task Deficits in Young Rats.

The observation that entorhinal input to the hippocampus declines in old age is well established across human studies and in animal models. This loss of perforant path fibers is exaggerated in individuals with episodic memory deficits and Mild Cognitive Impairment, suggesting that perforant path integrity is associated with progression to Alzheimer's Disease. During normal aging, behaviors that measure the ability of a study participant to discriminate between stimuli that share features is particularly sensitive to perforant fiber loss.