Formation of itraconazole-succinic acid cocrystals by gas antisolvent cocrystallization.

Cocrystals of itraconazole, an antifungal drug with poor bioavailability, and succinic acid, a water-soluble dicarboxylic acid, were formed by gas antisolvent (GAS) cocrystallization using pressurized CO(2) to improve itraconazole dissolution. In this study, itraconazole and succinic acid were simultaneously dissolved in a liquid solvent, tetrahydrofuran, at ambient conditions. The solution was then pressurized with CO(2), which decreased the solvating power of tetrahydrofuran and caused crystallization of itraconazole-succinic acid cocrystals.

Single-step preparation and deagglomeration of itraconazole microflakes by supercritical antisolvent method for dissolution enhancement.

Itraconazole (ITZ) microflakes were produced by supercritical antisolvent (SAS) method and simultaneously mixed with pharmaceutical excipients in a single step to prevent drug agglomeration. Simultaneous ITZ particle formation and mixing with fast-flo lactose (FFL) was performed in a high-pressure stirred vessel at 116 bar and 40 °C by the SAS-drug excipient mixing (SAS-DEM) method. The effects of stabilizers, such as sodium dodecyl sulfate and poloxamer 407 (PLX), on particle formation and drug dissolution were studied.

Evaluation of polymer matrices for an adsorptive approach to plasma detoxification.

Acute liver failure arises when potentially toxic metabolites accumulate in the bloodstream because of a breakdown in liver function. New extracorporeal systems combining membrane and adsorbent technologies are being developed to replace critical liver detoxification functions between diagnosis and transplantation. This study addresses the adsorption of representative plasma components on four different hydrophobic, polymeric adsorbents for possible use in an extracorporeal hemodialysis device.