Zr-pro-MMP-9 F(ab') detects colitis induced intestinal and kidney fibrosis.

Intestinal fibrosis is a common complication of inflammatory bowel disease but remains difficult to detect. Matrix metalloproteases (MMPs) have key roles in fibrosis and are therefore potential targets for fibrosis detection. We determined whether immunoPET of F(ab') antibody fragments targeting MMPs detects colitis induced colonic fibrosis.

Rapid and automated production of [Ga]gallium chloride and [Ga]Ga-DOTA-TATE on a medical cyclotron.

Introduction: The demand for Gallium-68 (Ga) for labelling PET radiopharmaceuticals has increased over the past few years. Ga is obtained through the decayed parent radionuclide Ge using commercial Ge/Ga generators. The principal limitation of commercial Ge/Ga generators is that only a limited and finite quantity of Ga (<1.

Anion-π interactions of hexaaryl[3]radialenes.

Coordination polymers and discrete metallo-supramolecular assemblies of hexaaryl[3]radialene compounds exhibit intriguing structures with short anion to π-centroid distances in the solid-state. Furthermore, these [3]radialene compounds display useful photophysical and electrochemical properties that make them ideal as potential platforms for anion receptors. In this study, hexafluoro[3]radialene was optimized to the MP2/aug-cc-pVTZ level of theory, and its complexes with halide anions were optimized to HF/6-31G++(d,p), MP2/6-31G++(d,p), M06-2X/6-31G++(d,p), and M06-2X/6-311G++(d,p) levels of theory.

Fluorescent hexaaryl- and hexa-heteroaryl[3]radialenes: Synthesis, structures, and properties.

The syntheses of three new [3]radialenes - hexakis(3,5-dimethylpyrazolyl)-, hexakis(3-cyanophenyl)-, and hexakis(3,4-dicyanophenyl)[3]radialene (1-3) - are reported. Compound 3 is obtained in five steps with an excellent yield of 76% in the key step. Compared to that, the respective steps of the syntheses of 1 and 2 result in lower yields.