Publications by authors named "Coulson Kgathi"
Article Synopsis
- * Of the 8,551 participants followed for 29 months, 147 individuals (1.7%) contracted HIV, with different risk factors identified for males and females based on their relationships and community HIV prevalence.
- * The findings suggest that machine learning can effectively pinpoint key predictors of HIV risk, which could enhance the targeting of HIV prevention strategies in Botswana.
Article Synopsis
- The study analyzed the safety and COVID-19 incidence of the AZD1222 vaccine in Botswana over nearly a year, involving more than 10,000 participants.
- It included different groups based on vaccination series and compared the incidence of adverse events between those with and without prior COVID-19 infection.
- The results showed no severe COVID-19 cases or deaths, mostly mild adverse events, and suggested that AZD1222 is effective regardless of HIV status.
Introduction: Studies have reported a higher risk of suboptimal neurodevelopment among children who are HIV-exposed uninfected (HEU) compared to children HIV-unexposed uninfected (HUU). Actual academic performance among school-aged children by HIV exposure status has not been studied.
Methods: Academic performance in Mathematics, Science, English, Setswana and overall among children enrolled in the Botswana-based FLOURISH study who were attending public primary school and ranging in age from 7.
Background: HIV-1 is endemic in Botswana. The country's primary challenge is identifying people living with HIV who are unaware of their status. We evaluated factors associated with undiagnosed HIV infection using HIV-1 phylogenetic, behavioural, and demographic data.
View Article and Find Full Text PDFPopulation uptake of HIV testing, treatment, viral suppression, and male circumcision following a community-based intervention in Botswana (Ya Tsie/BCPP): a cluster-randomised trial.
Lancet HIV
June 2020
Background: In settings with high HIV prevalence and treatment coverage, such as Botswana, it is unknown whether uptake of HIV prevention and treatment interventions can be increased further. We sought to determine whether a community-based intervention to identify and rapidly treat people living with HIV, and support male circumcision could increase population levels of HIV diagnosis, treatment, viral suppression, and male circumcision in Botswana.
Methods: The Ya Tsie Botswana Combination Prevention Project study was a pair-matched cluster-randomised trial done in 30 communities across Botswana done from Oct 30, 2013, to June 30, 2018.
Background: The feasibility of reducing the population-level incidence of human immunodeficiency virus (HIV) infection by increasing community coverage of antiretroviral therapy (ART) and male circumcision is unknown.
Methods: We conducted a pair-matched, community-randomized trial in 30 rural or periurban communities in Botswana from 2013 to 2018. Participants in 15 villages in the intervention group received HIV testing and counseling, linkage to care, ART (started at a higher CD4 count than in standard care), and increased access to male circumcision services.