Publications by authors named "Cottin L"
Patients with essential thrombocythemia (ET) have a chronic evolution with a risk of hematological transformation associated with a dismal outcome. Since patients with resistance or intolerance have an adverse prognosis, it is important to identify which patient will respond to first-line treatment. We therefore aim to describe the association between additional mutations and response to first-line treatment in patients with ET.
View Article and Find Full Text PDFThere are currently no established biomarkers for predicting the therapeutic effectiveness of Vagus Nerve Stimulation (VNS). Given that neural desynchronization is a pivotal mechanism underlying VNS action, EEG synchronization measures could potentially serve as predictive biomarkers of VNS response. Notably, an increased brain synchronization in delta band has been observed during sleep-potentially due to an activation of thalamocortical circuitry, and interictal epileptiform discharges are more frequently observed during sleep.
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- A low allele burden (<20%) of the CALR driver mutation is present in 10.8% of patients with CALR-mutated myeloproliferative neoplasms (MPNs), primarily seen in essential thrombocythemia.
- Patients with this low allele burden tend to have a milder disease phenotype.
- Those with less than 20% allele burden also experience a slower progression of their condition compared to patients with a higher allele burden (≥20%).
Article Synopsis
- * Researchers analyzed 91 patients and found multiple gene mutations, with FLT3 and NPM1 being the most common; specific mutations were linked to remission success, treatment resistance, and post-relapse mortality.
- * Short-term outcomes were best predicted by general health and performance status, while long-term outcomes were better assessed using genomic classifications, highlighting the need for tailored prognostic systems for older patients, as existing models primarily focus on younger individuals.
Sleep intensity is adjusted by the length of previous awake time, and under tight homeostatic control by protein phosphorylation. Here, we establish microglia as a new cellular component of the sleep homeostasis circuit. Using quantitative phosphoproteomics of the mouse frontal cortex, we demonstrate that microglia-specific deletion of TNFα perturbs thousands of phosphorylation sites during the sleep period.
View Article and Find Full Text PDFIn order to standardize cellular hematology practices, the French-speaking Cellular Hematology Group (Groupe Francophone d'Hématologie Cellulaire, GFHC) focused on Perls' stain. A national survey was carried out, leading to the proposal of recommendations on insoluble iron detection and quantification in bone marrow. The criteria presented here met with a "strong professional agreement" and follow the suggestions of the World Health Organization's classification of hematological malignancies.
View Article and Find Full Text PDFVEXAS (vacuoles, E1 enzyme, X-linked, auto-inflammatory, somatic) syndrome is an inflammatory disorder with hematological and systemic features. A recent study demonstrated that the dermal infiltrate in neutrophilic dermatosis from VEXAS patients is derived from the pathological UBA1-mutated myeloid clone. Neutrophilic dermatosis is, however, only one of the various skin involvements observed in VEXAS syndrome.
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- Researchers aimed to enhance predictions for left ventricular remodeling (LVR) within three months post-myocardial infarction (MI) by utilizing machine learning techniques.
- A study involved 443 ST-elevation MI patients at Angers University Hospital, collecting various clinical, biological, and CMR imaging data to analyze the incidence of LVR using advanced algorithms.
- The most effective machine learning model, a neural network using seven key variables, achieved a higher accuracy (AUC of 0.78) and sensitivity (92%) compared to conventional models, highlighting the benefits of data-driven approaches in predicting LVR.
Article Synopsis
- Immunoglobulin replacement therapy is often recommended for severe hypogammaglobulinemia in patients after allogeneic hematopoietic stem cell transplantation (allo-HSCT), but its link to increased infection risk remains unconfirmed.
- A study involving 76 allo-HSCT patients found no significant difference in gamma globulin levels between those who had infections and those who did not during the first 100 days post-transplant.
- The findings suggest that humoral deficiency has a limited role in immune deficiency during this period, raising questions about the necessity of immunoglobulin replacement therapy.
Article Synopsis
- The study looked at how different gene mutations affect the health of people with myelofibrosis, a type of blood disease.
- Researchers analyzed 479 patients and grouped them based on specific mutations to see how these groups relate to worsening conditions or death.
- They found that mutations in certain genes like TP53 and high-risk genes made it more likely for patients to get worse or die, while a mutation in the ASXL1 gene alone didn’t have a significant negative impact.
,'-Bis[2,6-bis-(1-methyl-eth-yl)phen-yl]pyridine-4-carboximidamide toluene hemisolvate.
Acta Crystallogr E Crystallogr Commun
February 2021
The title compound, CHN·0.5CH, is a symmetrically ,'-disubstituted aryl-amidine containing a 4-pyridyl substituent on the carbon atom of the N-C-N linkage and bulky 2,6-diiso-propyl-phenyl groups on the nitro-gen atoms. It crystallizes in the configuration and its amidine C-N bonds present amine [1.
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- - Among myeloproliferative neoplasms, polycythemia vera (PV) and essential thrombocythemia (ET) are chronic conditions that can evolve into leukemia, although this progression is rare and has a poor prognosis.
- - A study involving 49 cases of leukemic transformations in PV and ET identified three distinct molecular groups that correlate with different timelines for transformation based on specific genetic mutations.
- - The research revealed that some mutations were present during the chronic phase of the disease, but not all mutations were detectable before the onset of leukemia, indicating that the transformation process may involve varying molecular mechanisms over time.
Article Synopsis
- * Results show that patients with incomplete chimerism have a higher risk of relapse and lower overall survival rates, with a significant correlation between increased recipient DNA and relapse risk.
- * Both chimerism monitoring and WT1 quantification demonstrated comparable effectiveness in predicting relapse, indicating that CD3-negative chimerism monitoring could be a valuable tool for patients lacking specific molecular markers.
Article Synopsis
- In myeloproliferative neoplasms (MPN), the measurement of the JAK2V617F allele burden is important for patient prognosis, but the role of CALR mutations is less defined.
- A study involving 45 CALR-mutated essential thrombocythaemia patients combined next-generation sequencing with CALR allele burden evaluation and found TET2 as the most common mutation.
- The research revealed that an increase in CALR allele burden during follow-up is linked to disease progression, suggesting that monitoring this allele may have clinical significance.
Article Synopsis
- Classical Philadelphia-negative myeloproliferative neoplasms include Polycythemia Vera (PV), Essential Thrombocythemia (ET), and Primary Myelofibrosis (PMF), linked to specific driver mutations in the JAK2, CALR, or MPL genes.
- * The study found that the WT1 transcript is overexpressed in patients with PMF and PV compared to healthy controls, with significantly higher levels in PMF.
- * High levels of the WT1 transcript in PMF are associated with older age, splenomegaly, and thrombocytopenia, and can be a reliable diagnostic marker for PMF when levels exceed 10 copies/10ABL1.
Article Synopsis
- Philadelphia-negative classical myeloproliferative neoplasms (MPN) involve clonal diseases linked to mutations in JAK2, MPL, or CALR, with additional mutations in various genes influencing prognosis.
- This study analyzed 50 patients with JAK2V617F positive polycythemia vera (PV) and essential thrombocythemia (ET) using an 18-gene panel, finding that those with disease progression were more likely to have additional mutations at diagnosis.
- Results indicated that 100% of patients with two or more mutations experienced disease progression after three years, suggesting mutation screening may help identify high-risk patients for better management.
A high number of circulating CD34+ cells has been advocated to distinguish primary myelofibrosis from other Philadelphia-negative myeloproliferative neoplasms. We re-evaluated the diagnostic interest of measuring circulating CD34+ cells in 26 healthy volunteers and 256 consecutive patients at diagnosis for whom a myeloproliferative neoplasm was suspected. The ROC curve analysis showed that a number of CD34+ <10/μl excludes the diagnosis of primary myelofibrosis with a sensitivity of 97 % and a specificity of 90 % (area under the curve: 0.
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