Publications by authors named "Costin-S Caracoti"
Article Synopsis
- Meningococcus is a Gram-negative bacterium that can cause serious infections, particularly meningitis, and while it typically has a protective capsule, unencapsulated strains also have clinical significance.
- The study focused on creating a mouse model of meningitis using a capsule-deficient strain to evaluate the effectiveness of different antimicrobial treatments.
- Results showed that the strain had multiple virulence factors, and while the untreated group had a low survival rate, certain antibiotic treatments significantly improved survival, with rates reaching up to 81.25%.
Nowadays, thanks to nanotechnological progress, which itself guides us more and more closely toward not only the efficient design of innovative nanomaterials or nanostructures, but to the improvement of their functionality, we benefit from an important asset in the battle against pathogenic illnesses. Herein, we report a versatile biocompatible plasmonic nanoplatform based on a Whatman paper incorporating positively-charged gold nanospherical particles via the immersion approach. The morphological characterization of the as-engineered-plasmonic paper was examined by SEM (scanning electron microscopy) and HRTEM (high-resolution transmission electron microscopy) investigations, while its surface chemical modification with a synthetic polypeptide, specifically RRWHRWWRR-NH2 (P2), was proved by monitoring the plasmonic response of loaded gold nanospheres and the emission signal of P2 via fluorescence spectroscopy.
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