Publications by authors named "Costanzo Padovano"
Article Synopsis
- Notch signaling is crucial for tissue development and affects human osteoclast differentiation, with Notch1 showing conflicting roles in human versus mouse osteoclast formation.
- Our study reveals that active Notch1 signaling blocks the differentiation of human mononuclear CD14 cells into osteoclasts while promoting expansion of specific cell subsets during osteoclastogenesis.
- We found that IL7R is a downstream target of Notch1, highlighting a new interaction that enhances the development of osteoclast progenitors, and showcasing distinct gene expression and signaling pathways involved in this process.
Background: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy, characterized by restricted cellular subsets with asymmetrically enriched leukemia initiating cell (LIC) activity. Nonetheless, it is still unclear which signaling programs promote LIC maintenance and progression.
Methods: Here, we evaluated the role of the biological clock in the regulation of the molecular mechanisms and signaling pathways impacting the cellular dynamics in T-ALL through an integrated experimental approach including gene expression profiling of shRNA-modified T-ALL cell lines and Chromatin Immunoprecipitation Sequencing (ChIP-Seq) of leukemic cells.
T-cell acute lymphoblastic leukemia (T-ALL) is a T-cell malignancy characterized by cell subsets and enriched with leukemia-initiating cells (LICs). β-Catenin modulates LIC activity in T-ALL. However, its role in maintaining established leukemia stem cells remains largely unknown.
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