Publications by authors named "Costanza Giardina"
Article Synopsis
- Alzheimer disease (AD) is a complex age-related condition characterized by the formation of plaques and tangles in the brain, along with oxidative stress and inflammation; current treatments mainly focus on symptom management with limited success.
- Recent research has shown that Oxotremorine-M (Oxo), a compound that activates certain acetylcholine receptors, can promote neuron health and combat oxidative stress and inflammation in the brain.
- In laboratory testing on neuroblastoma cells exposed to harmful amyloid-beta peptide, Oxo treatment was found to improve cell survival, promote neurite growth, and protect against DNA damage, suggesting it could be a promising multi-target therapy for AD.
Article Synopsis
- Guanosine (GUO) is a significant signaling molecule involved in various cellular processes but is still not fully understood in its neuromodulatory role.
- GUO specifically regulates potassium (K) channel activity in human neuroblastoma SH-SY5Y cells, which affects cellular excitability.
- The study findings indicate that GUO's effects are enhanced when combined with adenosine (ADO), suggesting a functional interaction between these two molecules in modulating neural activity.
Tested in vitro on SH-SY5Y neuroblastoma cells, grapefruit IntegroPectin is a powerful protective, antioxidant and antiproliferative agent. The strong antioxidant properties of this new citrus pectin, and its ability to preserve mitochondrial membrane potential and morphology, severely impaired in neurodegenerative disorders, make it an attractive therapeutic and preventive agent for the treatment of oxidative stress-associated brain disorders. Similarly, the ability of this pectic polymer rich in RG-I regions, as well as in naringin, linalool, linalool oxide and limonene adsorbed at the outer surface, to inhibit cell proliferation or even kill, at high doses, neoplastic cells may have opened up new therapeutic strategies in cancer research.
View Article and Find Full Text PDFLemon IntegroPectin obtained via hydrodynamic cavitation of organic lemon processing waste in water shows significant neuroprotective activity in vitro, as first reported in this study investigating the effects of both lemon IntegroPectin and commercial citrus pectin on cell viability, cell morphology, reactive oxygen species (ROS) production, and mitochondria perturbation induced by treatment of neuronal SH-SY5Y human cells with HO. Mediated by ROS, including HO and its derivatives, oxidative stress alters numerous cellular processes, such as mitochondrial regulation and cell signaling, propagating cellular injury that leads to incurable neurodegenerative diseases. These results, and the absence of toxicity of this new pectic substance rich in adsorbed flavonoids and terpenes, suggest further studies to investigate its activity in preventing, retarding, or even curing neurological diseases.
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