Down syndrome is a common genetic disorder that usually doesn't get worse, but some people can experience a special type called Down Syndrome Regression Disorder (DSRD) that leads to a sudden decline in skills.
DSRD often happens in late teens and can cause problems like losing language, daily living skills, and feeling really sad or confused.
Treatment is tricky; some medicines don't work well, but anti-inflammatory drugs have helped improve symptoms for some patients, so it’s important to get help early if these problems show up.
Impairments in social cognition have been frequently described in 22q11.2 deletion syndrome (22q11.2DS) and are thought to be a hallmark of difficulties in social interactions.