Publications by authors named "Costantinos Sioutas"
Article Synopsis
- Traffic-related air pollution particulate matter (TRAP-PM) is linked to a higher risk of Alzheimer's Disease, particularly through increased production of amyloid Aβ peptides in rodent models.
- Experiments with J20 mice and N2a cells showed that exposure to nano-sized TRAP-PM led to oxidative stress and changes in lipid rafts, which in turn enhanced the production of Aβ peptides in brain regions affected by Alzheimer's.
- The antioxidant N-acetyl-cysteine (NAC) was found to reduce the oxidative damage and subsequent Aβ production, highlighting the potential of targeting lipid rafts to mitigate air pollution's detrimental effects on neurodegenerative processes.
The elderly and individuals who have chronic obstructive pulmonary disease (COPD) may be sensitive to particulate matter (PM) air pollution. We evaluated short-term health responses of 13 elderly volunteers with COPD and 6 age-matched healthy adults to controlled exposures of ambient PM pollution in suburban Los Angeles. Using a Harvard particle concentrator and a whole-body chamber, we exposed each person on separate occasions to approximately 200 microg/m(3) concentrated ambient particles (CAP) less than 2.
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