[The clinicopsychological and therapeutic significance in the depression-pain relationship].

The frequency of depression-pain association, gives the authors the opportunity of evaluating the actual pattern of managing pain according to its sensory-discriminatory, affective-emotional, cognitive and behavioral features. The neurophysiologic, affective and psychologic factors generally correlate in the induction and evolution of pain, being dependent on the individual reactivity environmental and socio-cultural relations. The efficacy of antidepressive drugs in the therapy of pain, explained by their action on the serotoninergic systems, advocates the clinical relationship depression-pain, but also their analgesic properties independent from the thymoanaleptic effect.

Psychopathological relationships in depressive illness.

The evolution of the clinical concepts regarding depressive syndromes underlines the need for correlating the epidemiological, clinical and etiopathogenic data for elaborating the classification, quantification and psychopathologic assessment systems. The psychological investigation, complementary to clinical examination and adapted to patient's subjective condition, requires an improvement of its methods in view of bringing more information necessary for stating the differential psychodiagnosis and for a proper psychotherapy. The analysis of motivations and the psychopathologic relationships in the depressive states render evident the factorial complexity and the need of a clinical, psychological, genetic, biochemical, experimental and therapeutic approach.

[The significance of the anxiety factor in neurotiform-depressive states].

As part of the clinical psychological investigations, tests were used for determining the share of anxiety factor in the neurotiform-depressive states. The constituent elements of anxiety factors are discussed, those which might have significance being outlined. The authors plead for the use of insight therapy, as part of the complex clinical treatment, in those cases where the performed tests indicate the likelihood of a good response to such a therapy.

[Trends in the classification of depressive states].

The evolution of the clinical concept of depression from the viewpoint of actual epidemiological data and classification systems is presented. The classification difficulties, due to the reference criteria and absence of some concordant data, which lead to the elaboration of some systematizations prevalently syndromic, are revealed. The uncertainty of the nosological framing of the depressive states is reflected in the diagnostic disagreements of the various doctrinaire orientations in psychiatry.

[Lithium carbonate (Contemnol--Spofa). A clinical study].

The estimation of the present day stage in the therapy with lithium salts allowed the authors some considerations on the mechanisms of action and pharmacodynamics of lithium ion, as well as on the indications and counterindications, side effects and therapeutical management. Thus, the authors have analysed the findings of a simple-blind clinical study on lithium carbonate (Contemnol--Spofa) in a series of 15 inpatients. The research methodology included the thorough examination of the patients, blood lithium screening, psychological investigations and laboratory tests on the basis of an itemized investigation card.

[Clinical observations of treatment with Lyorodin-depot (Jenapharm)].

According to the indications of fluphenazin decanoate in the long-term treatment in schizophrenia the authors analyse the findings of a simple blind study of Lyorodin-depot on a sample of 20 inpatients. The drug was administered at intervals of 21 days for 18 weeks under clinical surveillance. The method consisted of patients' follow-up on an itemized card, psychological checkups and para-clinical investigations.

[Standardized scale instruments for evaluating the relational meanings of motivation, pathogenesis and care in alcoholism].

The authors give synthesis of five scale methods for alcoholism (Alcoholism Severity Scale, Mac Andrew Scale, Bell Alcoholism Scale of Adjustment, Manson Evaluation and Iowa Alcoholic Intake Schedule), four scale means of the type of Psychological tests (Alcadd Test, Michigan Alcoholism Screening Test, Mortimer-Filkins Test and Essential Reactive Alcoholism Dimension) and three procedures of the type of personality inventory and questionnaire (Drinking Behaviour Interview, Alcoholism Assessment Interview and Alcoholism Use Questionnaire) tools that were at the basis of the construction of a "Scale of Estimating Medical Implications in Alcoholism" conceived experimented and validated in the psychiatric clinic of Iaşi.

[The treatment of depressive states with opipramol (Insidon--Geigy)].

The authors analyse the findings of a clinical simple-blind trial of the drug Insidon--Geigy in depressive states. This drug was administered in monotherapy for 28 days in average doses of 150 mg daily in a series of 20 inpatients of both sexes and aged 20-60 years, diagnosed with neurotic depressive state. The efficiency of the treatment and its tolerance were estimated on a special Ciba-Geigy Pharma International investigation card through clinical observation, scoring of clinical items, psychological check-up and Hamilton's scale for depression at 0-7-14-21 and 28 days, paraclinical investigations, computer processing (TIM-S) on the basis of a program (in BETA BASIC language in 3.

[Comparative clinico-therapeutic study of amitriptyline hydrochloride (Tryptizol/amitriptyline)].

As compared to the psychopharmacological profile of amitriptyline hydrochloride the authors analyse the findings of a comparative clinical trial amitriptyline versus Tryptizol regarding their efficacy in neurotic and presenile depression. 170 inpatients divided into four comparative series were investigated. The drugs were administered according to the same scheme in monotherapy for 30 days.