Machine Learning and BMI Improve the Prognostic Value of GAP Index in Treated IPF Patients.

Patients affected by idiopathic pulmonary fibrosis (IPF) have a high mortality rate in the first 2-5 years from diagnosis. It is therefore necessary to identify a prognostic indicator that can guide the care process. The Gender-Age-Physiology (GAP) index and staging system is an easy-to-calculate prediction tool, widely validated, and largely used in clinical practice to estimate the risk of mortality of IPF patients at 1-3 years.

Three endobronchial white trees in a patient with mild hemoptysis: A rare case of broncholithiasis.

Broncholithiasis is a rare and most often ignored condition characterized by the presence of calcified or ossified materials in the bronchus. The patient can be asymptomatic or commonly present with coughing. It is important to correctly identify this disease because in many cases it can cause hemoptysis and rarely lithoptysis.

Real life experience of molnupiravir as a treatment of SARS-CoV-2 infection in vaccinated and unvaccinated patients: a letter on its effectiveness at preventing hospitalization.

Background: The SARS-CoV-2 pandemic has prompted clinicians to develop an early and effective treatment of viral infections. To date, vaccines, monoclonal antibodies, and antivirals are the cornerstone of therapy for SARS-CoV-2. AIFA approved the prescription of molnupiravir on 30/12/2021.

Effect of Hypoxia-Induced Micro-RNAs Expression on Oncogenesis.

MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. An aberrant regulation of gene expression by miRNAs is associated with numerous diseases, including cancer. MiRNAs expression can be influenced by various stimuli, among which hypoxia; however, the effects of different types of continuous hypoxia (moderate or marked) on miRNAs are still poorly studied.