Identification and characterization of novel ETV4 splice variants in prostate cancer.

ETV4, one of ETS proteins overexpressed in prostate cancer, promotes migration, invasion, and proliferation in prostate cells. This study identifies a series of previously unknown ETV4 alternatively spliced transcripts in human prostate cell lines. Their expression has been validated using several unbiased techniques, including Nanopore sequencing.

ETV4 promotes late development of prostatic intraepithelial neoplasia and cell proliferation through direct and p53-mediated downregulation of p21.

Background: ETV4 is one of the ETS proteins overexpressed in prostate cancer (PC) as a result of recurrent chromosomal translocations. In human prostate cell lines, ETV4 promotes migration, invasion, and proliferation; however, its role in PC has been unclear. In this study, we have explored the effects of ETV4 expression in the prostate in a novel transgenic mouse model.

Simulation of pulsed ELF magnetic fields generated by GSM mobile phone handsets for human electromagnetic bioeffects research.

Human provocation studies that investigate the effects of Global System for Mobiles (GSM) communication systems on the brain have focused on Radio Frequency (RF) exposure. We wish to further extend such study by investigating the effect of both RF and Extremely Low Frequency (ELF) field exposure, the latter generated by the GSM handset's battery switching. The use of a commercial handset as an exposure source for such investigations is problematic for a number of reasons and therefore a simulated exposure source, capable of producing both RF and ELF components of exposure, is desirable.