Publications by authors named "Cosette Tomita"
Total-body imaging of mu-opioid receptors with [C]carfentanil in non-human primates.
Eur J Nucl Med Mol Imaging
September 2024
Article Synopsis
- This study investigated mu-opioid receptors (MORs) distribution in the body of rhesus macaques using PET imaging with the radioligand [C]carfentanil.
- Researchers measured MOR binding under different conditions, including baseline and after administering antagonists like naloxone and GSK1521498.
- Results showed that both naloxone and GSK1521498 significantly blocked MORs in the brain and spinal cord, indicating their potential as treatments for opioid use disorder, with GSK1521498 being a possible alternative to naloxone for reversing overdoses.
Abnormal α-synuclein (α-syn) aggregation characterizes α-synucleinopathies, including Parkinson's disease (PD) and multiple system atrophy (MSA). However, no suitable positron emission tomography (PET) radiotracer for imaging α-syn in PD and MSA exists currently. Our structure-activity relationship studies identified 4-methoxy--(4-(3-(pyridin-2-yl)-3,8-diazabicyclo[3.
View Article and Find Full Text PDF