Publications by authors named "Cosette Craig"
Microfluidics offer user-friendly liquid handling for a range of biochemical applications. 3D printing microfluidics is rapid and cost-effective compared to conventional cleanroom fabrication. Typically, microfluidics are 3D printed using digital light projection (DLP) stereolithography (SLA), but many models in use are expensive (≥$10,000 USD), limiting widespread use.
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- Adequate levels of antiretroviral (ARV) medications are essential for effective HIV treatment and prevention, as monitoring these levels can help prevent issues like treatment failure or drug resistance.
- Traditional methods for measuring ARVs, such as liquid chromatography-tandem mass spectrometry, are slow and costly, hindering timely intervention.
- The new REACT assay allows rapid detection of non-nucleoside reverse transcriptase inhibitors (NNRTIs) using a simple portable reader, which could enhance HIV treatment outcomes in point-of-care settings.
Sufficient drug concentrations are required for efficacy of antiretroviral drugs used in HIV care and prevention. Measurement of nucleotide analogs, included in most HIV medication regimens, enables monitoring of short- and long-term adherence and the risk of treatment failure. The REverSe TRanscrIptase Chain Termination (RESTRICT) assay rapidly infers the concentration of intracellular nucleotide analogs based on the inhibition of DNA synthesis by HIV reverse transcriptase enzyme.
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