Publications by authors named "Corynn Appolonia"
Article Synopsis
- Chronic alcohol consumption negatively affects lung immunity, making individuals with alcohol use disorder more prone to serious inflammatory lung conditions.
- Research using human lung transcriptomics and mouse models indicates that males experience greater disruption of lung immunity due to alcohol than females.
- The study highlights that alcohol significantly downregulates immune-related genes in the lungs, suggesting immunometabolic changes and reduced mTOR signaling play a key role in this immune dysregulation.
Heavy alcohol drinking has negative health effects in multiple organs. It predisposes lungs to inflammatory conditions associated with acute lung injury and increased incidence of pneumonia and sepsis, which may lead to death due to acute respiratory distress syndrome in some individuals with alcohol use disorder (AUD). In general, rodent models of alcohol exposure either do not recapitulate multiple organ injuries as seen in humans or require longer duration to establish tissue injury and inflammation.
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- - Alaska Native (AN) people have the highest known rate of colorectal cancer (CRC) globally, while rural Africans (RA) have the lowest, suggesting that dietary differences may influence CRC risk through their effect on gut microbiota.
- - A study compared the dietary habits and gut microbiota of healthy middle-aged volunteers from AN and RA, revealing that AN participants had higher fat and animal protein intake, lower fiber, and a distinct microbial composition linked to tumor-promoting metabolites.
- - Results showed that AN individuals had adenomatous polyps and lower butyrate levels, a tumor-suppressive metabolite, alongside higher levels of deoxycholic acid, a tumor-promoting substance; thus, the differing metabolite profiles
Article Synopsis
- The review examines how fiber and fat in the diet affect the risk of colorectal cancer (CRC), highlighting a significant relationship between fiber intake and reduced CRC risk.
- Increased dietary fiber is linked to higher butyrate production by gut bacteria, which has anti-cancer properties, while high-fat diets can elevate CRC risk by promoting the production of harmful bile acids.
- The study suggests that managing fiber consumption and limiting fat intake could be effective strategies to lower CRC risk, although more research is needed to understand the underlying mechanisms and interactions between these dietary components.
In utero exposure to maternal diabetes impairs nephron progenitor differentiation.
Am J Physiol Renal Physiol
November 2019
The incidence of diabetes mellitus has significantly increased among women of childbearing age, and it has been shown that prenatal exposure to maternal diabetes increases the risk of associated congenital anomalies of the kidney. Congenital anomalies of the kidney are among the leading causes of chronic kidney disease in children. To better understand the effect of maternal diabetes on kidney development, we analyzed wild-type offspring (DM_Exp) of diabetic mice (Akita mice).
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