The Virtual Pediatric Airways Workbench.

The Virtual Pediatric Airways Workbench (VPAW) is a patient-centered surgical planning software system targeted to pediatric patients with airway obstruction. VPAW provides an intuitive surgical planning interface for clinicians and supports quantitative analysis regarding prospective surgeries to aid clinicians deciding on potential surgical intervention. VPAW enables a full surgical planning pipeline, including importing DICOM images, segmenting the airway, interactive 3D editing of airway geometries to express potential surgical treatment planning options, and creating input files for offline geometric analysis and computational fluid dynamics simulations for evaluation of surgical outcomes.

The spatial segregation of pericentric cohesin and condensin in the mitotic spindle.

In mitosis, the pericentromere is organized into a spring composed of cohesin, condensin, and a rosette of intramolecular chromatin loops. Cohesin and condensin are enriched in the pericentromere, with spatially distinct patterns of localization. Using model convolution of computer simulations, we deduce the mechanistic consequences of their spatial segregation.

FluoroSim: A Visual Problem-Solving Environment for Fluorescence Microscopy.

Fluorescence microscopy provides a powerful method for localization of structures in biological specimens. However, aspects of the image formation process such as noise and blur from the microscope's point-spread function combine to produce an unintuitive image transformation on the true structure of the fluorescing molecules in the specimen, hindering qualitative and quantitative analysis of even simple structures in unprocessed images. We introduce FluoroSim, an interactive fluorescence microscope simulator that can be used to train scientists who use fluorescence microscopy to understand the artifacts that arise from the image formation process, to determine the appropriateness of fluorescence microscopy as an imaging modality in an experiment, and to test and refine hypotheses of model specimens by comparing the output of the simulator to experimental data.

Interactive visualization of intercluster galaxy structures in the horologium-reticulum supercluster.

We present GyVe, an interactive visualization tool for understanding structure in sparse three-dimensional (3D) point data. The scientific goal driving the tool's development is to determine the presence of filaments and voids as defined by inferred 3D galaxy positions within the Horologium-Reticulum supercluster (HRS). GyVe provides visualization techniques tailored to examine structures defined by the intercluster galaxies.