Publications by authors named "Cory Manly"

We report a patient with multiple endocrine neoplasia type 1 with pancreatic polypeptide (PP) secreting subcentimeter pancreatic neuroendocrine tumors (pNETs) treated with octreotide and review the current literature that pertains to the management of these patients. Clinical data, laboratory results, and imaging were reviewed. A literature search was performed in PUBMED using combinations of the terms "multiple endocrine neoplasia type 1," "somatostatin," octreotide," "pancreatic polypeptide," and "pancreatic tumor.

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Exploring the mountains is a highly rewarding past time; however, certain high-altitude exposures can lead to dermatologic manifestations. In this review article, the authors will describe cold, solar, and severe weather that one may experience when spending time outdoors. Factors such as increased ultraviolet radiation, temperature extremes, and low partial pressure of oxygen, along with human physiologic parameters also contribute to disease severity and presentation.

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Mountains are home to numerous organisms known to cause skin disease. Bites, stings, poisons, chemicals, toxins, trauma, and infections all contribute to this end. Numerous plants, animals, fungi, bacteria, viruses, and protozoa are responsible.

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This represents the first report of laserspray ionization vacuum (LSIV) with operation directly from atmospheric pressure for use in mass spectrometry. Two different types of electrospray ionization source inlets were converted to LSIV sources by equipping the entrance of the atmospheric pressure inlet aperture with a customized cone that is sealed with a removable glass plate holding the matrix/analyte sample. A laser aligned in transmission geometry (at 180° relative to the inlet) ablates the matrix/analyte sample deposited on the vacuum side of the glass slide.

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Article Synopsis
  • Matrix assisted inlet ionization (MAII) generates mass spectra similar to electrospray ionization without needing voltage or lasers, allowing direct introduction of dried samples into the mass spectrometer.
  • The technique focuses on conditions that enhance the formation of multiply charged ions, influenced by factors like desolvation processes, heat, and sample preparation conditions.
  • Research on over 100 compounds indicates that the physical properties of the matrix, including its morphology and vaporization characteristics, are more crucial for ion production than its chemical structure or functional groups.
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