Publications by authors named "Cory A Donovan"
Background: The literature lacks well-established benchmarks for expected time between screening mammogram to diagnostic imaging and then to core needle breast biopsy.
Methods: Timeliness of diagnostic imaging workup was evaluated using aggregate data from 2005 to 2019 submitted to The National Quality Measures for Breast Centers (NQMBC).
Results: A total of 419 breast centers submitted data for 1,805,515 patients on the time from screening mammogram to diagnostic imaging.
Article Synopsis
- Invasive lobular carcinoma (ILC) often leads to high re-excision rates after breast-conserving surgery, and the relationship between lesion size on various imaging techniques and actual tumor size is unclear.
- A study reviewed data from patients with stage I-III breast cancer who underwent surgery, using Pearson correlation analysis to compare tumor sizes from imaging (mammography, ultrasound, and MRI) to final pathology results.
- Results indicated that MRI correlated most closely with actual tumor size, but overall imaging sizes underestimated tumors frequently, and using MRI did not significantly reduce the need for re-excision.
Background: Young women with breast cancer (BC) have an increased risk of contralateral breast cancer (CBC) compared with older women. This may contribute to the rising rates of bilateral mastectomy (BM), but it is unclear if BM leads to improved outcomes.
Methods: A prospectively maintained database was reviewed.
Background: While nipple-sparing mastectomy (NSM) for the treatment of breast cancer is becoming more accepted, technical aspects are still evolving. Data regarding risk factors contributing to complications after NSM are limited. This study evaluated technical aspects on outcomes of NSM.
View Article and Find Full Text PDFImportance: Mutations in oncogenes AKT1, HRAS, and PIK3CA in breast cancers result in abnormal PI3K/Akt signaling and tumor proliferation. They occur in ductal carcinoma in situ, in breast cancers, and in breast cancer stem and progenitor cells (BCSCs).
Objectives: To determine if variability in clinical presentation at diagnosis correlates with PI3K/Akt mutations in BCSCs and provides an early prognostic indicator of increased progression and metastatic potential.