Synopsis of recent research by authors named "Corwin Nycholat"
- Corwin Nycholat's recent research focuses on glycan interactions, particularly how glycan structures and their modifications influence immune recognition through receptors like Siglecs, which are critical in immune response regulation.
- His work includes the development of chemoenzymatic synthesis methods for sulfated and sialylated glycans, as well as innovative biophysical techniques to quantify glycan-binding affinities, revealing important insights into how viruses like H3N2 influenza adapt to human glycan receptors.
- Nycholat also explores therapeutic applications, such as targeting CD22 on memory B cells to induce tolerances to allergens and enhancing gene delivery systems using glycan-ligand conjugates, indicating a translational aspect of his research aimed at improving allergy treatments and gene therapies.
