Impact of malnutrition and nutrition support in hospitalised patients with inflammatory bowel disease.

Background: Malnutrition is prevalent in patients with inflammatory bowel disease (IBD) and has been associated with worse clinical outcomes.

Aims: This observational study examines trends in protein-calorie malnutrition (PCM) amongst hospitalised IBD and non-IBD patients, and the association between (1) malnutrition and (2) nutrition support and hospitalisation outcomes.

Methods: We queried the Nationwide Readmissions Database from 2010 to 2018 for hospitalisations with and without IBD.

Analysis of milk production and greenhouse gas emissions as a function of extreme variations in forage production among French dairy farms.

Many studies that investigate mitigation strategies of greenhouse-gas (GHG) emissions from farming systems often build farm typologies from average data from multiple farms. Results from farm typologies are useful for general purposes but fail to represent variability in farm characteristics due to management practices or climate conditions, particularly when considering consequences of extreme environmental events. This limitation raises the issue of better distinguishing, within datasets of farms, farms that have average characteristics from those that deviate from average trends, in order to improve assessment of how climate variability influences farm performance.

Contribution of LCA to decision making: A scenario analysis in territorial agricultural production systems.

Territorial Life Cycle Assessment (TLCA) appears a promising method to support informed decision making of local actors in territorial agricultural production systems (TAPS), by assessing environmental impacts of agricultural activities and potential strategies. The objectives of this study were to i) adapt TLCA methodology to integrated environmental assessment of TAPS and ii) evaluate TLCA's contribution to supporting informed decision making by assessing scenarios of change in TAPS. A TLCA of the agricultural sector was performed for a territory in the Aube department in France, including main crops and animal production types from raw material extraction to the first stage of processing.

The IBD-associated long noncoding RNA regulates the balance between inflammatory and anti-inflammatory cytokine production after T-cell stimulation.

The inflammatory bowel diseases (IBD) are a complex set of chronic gastrointestinal inflammatory conditions arising from the interplay of genetic and environmental factors. This study focuses on noncoding RNA transcripts as potential mediators of IBD pathophysiology. One particular gene, interferon γ-antisense 1 (), has been consistently observed to be elevated in the intestinal mucosa of patients with actively inflamed IBD versus healthy controls.

Hepatitis C Virus Treatment in Patients With Chronic Kidney Disease and in Kidney Transplant Recipients.

An important interplay exists between hepatitis C virus (HCV) infection and chronic kidney disease (CKD). HCV infection is associated with an increased risk of morbidity and mortality in patients coinfected with CKD, and patients with CKD have an increased risk of HCV infection. Direct-acting antiviral (DAA) agents have changed the landscape of treatment with excellent sustained virologic response rates and fewer side effects than previously seen.

A cross-sectional analysis of cardiovascular disease in the hemophilia population.

Men with hemophilia were initially thought to be protected from cardiovascular disease (CVD), but it is now clear that atherothrombotic events occur. The primary objective of the CVD in Hemophilia study was to determine the prevalence of CVD and CVD risk factors in US older men with moderate and severe hemophilia and to compare findings with those reported in age-comparable men in the Atherosclerosis Risk in Communities (ARIC) cohort. We hypothesized if lower factor levels are protective from CVD, we would see a difference in CVD rates between more severely affected and unaffected men.

The ModERN Resource: Genome-Wide Binding Profiles for Hundreds of and Transcription Factors.

To develop a catalog of regulatory sites in two major model organisms, and , the modERN (model organism Encyclopedia of Regulatory Networks) consortium has systematically assayed the binding sites of transcription factors (TFs). Combined with data produced by our predecessor, modENCODE (Model Organism ENCyclopedia Of DNA Elements), we now have data for 262 TFs identifying 1.23 M sites in the fly genome and 217 TFs identifying 0.

Improving Estimates of Nitrogen Emissions for Life Cycle Assessment of Cropping Systems at the Scale of an Agricultural Territory.

In life cycle assessment (LCA), simple models are currently used to estimate cropping system nitrogen (N) emissions on farms. At large spatial scales (e.g.

Association of Fenofibrate Therapy With Long-term Cardiovascular Risk in Statin-Treated Patients With Type 2 Diabetes.

Importance: Patients with type 2 diabetes are at high risk of cardiovascular disease (CVD) in part owing to hypertriglyceridemia and low high-density lipoprotein cholesterol. It is unknown whether adding triglyceride-lowering treatment to statin reduces this risk.

Objective: To determine whether fenofibrate reduces CVD risk in statin-treated patients with type 2 diabetes.

Expected improvements in the quantitative remote sensing of optically complex waters with the use of an optically fast hyperspectral spectrometer-a modeling study.

Using simulated data, we investigated the effect of noise in a spaceborne hyperspectral sensor on the accuracy of the atmospheric correction of at-sensor radiances and the consequent uncertainties in retrieved water quality parameters. Specifically, we investigated the improvement expected as the F-number of the sensor is changed from 3.5, which is the smallest among existing operational spaceborne hyperspectral sensors, to 1.

Intra-session test-retest reliability of magnitude and structure of center of pressure from the Nintendo Wii Balance Board™ for a visually impaired and normally sighted population.

Individuals with visual impairment (VI) have irreparable damage to one of the input streams contributing to postural stability. Here, we evaluated the intra-session test-retest reliability of the Wii Balance Board (WBB) for measuring Center of Pressure (COP) magnitude and structure, i.e.

Optimal protective hypothermia in arrested mammalian hearts.

Many therapeutic hypothermia recommendations have been reported, but the information supporting them is sparse, and reveals a need for the data of target therapeutic hypothermia (TTH) from well-controlled experiments. The core temperature ≤35°C is considered as hypothermia, and 29°C is a cooling injury threshold in pig heart in vivo. Thus, an optimal protective hypothermia (OPH) should be in the range 29-35°C.

Environmental impacts of French and Brazilian broiler chicken production scenarios: an LCA approach.

This study compared the environmental burdens of two broiler chicken production systems in Brazil and two in France. One Brazilian system represents large-scale production in the Center-West region of the country; the other is a small-scale production in the South. One of the French systems represents an extensive broiler chicken production system, known as "Label Rouge"; the other is a standard system.

Kinetic characterization of an oxidative, cooperative HMG-CoA reductase from Burkholderia cenocepacia.

3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) is a key enzyme in endogenous cholesterol biosynthesis in mammals and isoprenoid biosynthesis via the mevalonate pathway in other eukaryotes, archaea and some eubacteria. In most organisms that express this enzyme, it catalyzes the NAD(P)H-dependent reduction of HMG-CoA to mevalonate. We have cloned and characterized the 6x-His-tagged HMGR from the opportunistic lung pathogen Burkholderia cenocepacia.

Emergy evaluation of contrasting dairy systems at multiple levels.

Emergy accounting (EmA) was applied to a range of dairy systems, from low-input smallholder systems in South Mali (SM), to intermediate-input systems in two regions of France, Poitou-Charentes (PC) and Bretagne (BR), to high-input systems on Reunion Island (RI). These systems were studied at three different levels: whole-farm (dairy system and cropping system), dairy-system (dairy herd and forage land), and herd (animals only). Dairy farms in SM used the lowest total emergy at all levels and was the highest user of renewable resources.

Effect of dairy production system, breed and co-product handling methods on environmental impacts at farm level.

Six dairy farms with the same on-farm area and milk production were compared. One farm (G-No) used grass as the sole forage for a herd of Normande cows, a dual-purpose breed. Three farms, with Holstein cows, varied forage for the herd from grass only (G-Ho) to low (G/LM-Ho) or high (G/HM-Ho) proportion of maize silage in the total forage area.

Effect of farming practices for greenhouse gas mitigation and subsequent alternative land use on environmental impacts of beef cattle production systems.

This study evaluated effects of farming practice scenarios aiming to reduce greenhouse gas (GHG) emissions and subsequent alternative land use on environmental impacts of a beef cattle production system using the life cycle assessment approach. The baseline scenario includes a standard cow-calf herd with finishing heifers based on grazing, and a standard bull-fattening herd using a diet mainly based on maize silage, corresponding to current farm characteristics and management by beef farmers in France. Alternative scenarios were developed with changes in farming practices.

Vicarious calibrations of HICO data acquired from the International Space Station.

The Hyperspectral Imager for the Coastal Ocean (HICO) presently onboard the International Space Station (ISS) is an imaging spectrometer designed for remote sensing of coastal waters. The instrument is not equipped with any onboard spectral and radiometric calibration devices. Here we describe vicarious calibration techniques that have been used in converting the HICO raw digital numbers to calibrated radiances.

Impact of signal-to-noise ratio in a hyperspectral sensor on the accuracy of biophysical parameter estimation in case II waters.

Errors in the estimated constituent concentrations in optically complex waters due solely to sensor noise in a spaceborne hyperspectral sensor can be as high as 80%. The goal of this work is to elucidate the effect of signal-to-noise ratio (SNR) on the accuracy of retrieved constituent concentrations. Large variations in the magnitude and spectral shape of the reflectances from coastal waters complicate the impact of SNR on the accuracy of estimation.

Soft tissue manipulation for single implant restorations.

Achievement of optimal aesthetics on implants in the anterior region can be difficult due to inherent differences to the natural dentition. An important consideration is the peri-implant soft tissues which can be modified to create a more natural emergence profile and contour. The methods with which this can be achieved vary as can methods for recording soft tissue changes and relaying this to technician colleagues.

Hyperspectral Imager for the Coastal Ocean: instrument description and first images.

The Hyperspectral Imager for the Coastal Ocean (HICO) is the first spaceborne hyperspectral sensor designed specifically for the coastal ocean and estuarial, riverine, or other shallow-water areas. The HICO generates hyperspectral images, primarily over the 400-900 nm spectral range, with a ground sample distance of ≈90 m (at nadir) and a high signal-to-noise ratio. The HICO is now operating on the International Space Station (ISS).

Darapladib: an emerging therapy for atherosclerosis.

Despite a reduction in cardiovascular risk conferred by therapies that modify circulating lipids, a need remains for novel treatments to further decrease the occurrence of complications of atherosclerotic cardiovascular diseases. Lipoprotein-associated phospholipase-A(2) is an important regulator of lipid metabolism and inflammation that circulates with lipoprotein particles and is carried into the arterial wall with low-density lipoprotein particles during the progression of atherosclerosis. Within the vessel wall, lipoprotein-associated phospholipase-A(2) releases small molecules that stimulate macrophage recruitment and evolution to foam cells, leading to plaque vulnerability.

Effects of intensive blood-pressure control in type 2 diabetes mellitus.

Background: There is no evidence from randomized trials to support a strategy of lowering systolic blood pressure below 135 to 140 mm Hg in persons with type 2 diabetes mellitus. We investigated whether therapy targeting normal systolic pressure (i.e.

Effects of cardiac autonomic dysfunction on mortality risk in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial.

Objective: Intensive therapy targeting normal blood glucose increased mortality compared with standard treatment in a randomized clinical trial of 10,251 participants with type 2 diabetes at high-risk for cardiovascular disease (CVD) events. We evaluated whether the presence of cardiac autonomic neuropathy (CAN) at baseline modified the effect of intensive compared with standard glycemia treatment on mortality outcomes in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial participants.

Research Design And Methods: CAN was assessed by measures of heart rate variability (HRV) and QT index (QTI) computed from 10-s resting electrocardiograms in 8,135 ACCORD trial participants with valid measurements (mean age 63.

Emerging inflammatory markers for assessing coronary heart disease risk.

Although assessment of traditional coronary heart disease risk factors can often stratify individuals into low- or high-risk categories, additional means are needed to more precisely classify people clinically defined as intermediate-risk, to guide the intensity of risk-reducing therapies. The recognition that inflammatory pathways are important in the progression of atherosclerosis and its complications has prompted investigation to identify circulating risk markers that may be useful in risk stratification. This article summarizes recent studies on the current use of an emerging group of inflammatory markers: soluble CD-40 ligand, interleukin-18, myeloperoxidase, B-type natriuretic peptides, secretory phospholipase A(2), lipoprotein-associated phospholipase A(2), and C-reactive protein.