Severe muscle damage after a short period of ischemia and reperfusion in an animal model.

Background: Skeletal muscle ischemia-reperfusion injuries result in a loss of contractile function, leading to limb disability or amputation. Ischemia causes hypoxia and cellular energy failure, which is aggravated by reperfusion due to the inflammatory response and oxidative stress. The consequences of the injury vary according to the duration of the period of ischemia and reperfusion.

Association between neuronal degeneration and supraphysiological doses of two types of anabolic steroids in rat brain.

The anabolic androgenic steroids (AAS) are natural compounds that are precursors or derivatives of testosterone and, as a consequence of indiscriminate use, cause irreversible neuronal effects. For this study, 70 brain samples were used from male Wistar rats, separated into 14 groups, divided into: control, sedentary, and exercise groups; in the concentrations: 5 mg, 10 mg, and 15 mg. Two different AAS were used: Testosterone Cypionate (TC) and Nandrolone Decanoate (ND).

[Behavior of sodium, chlorine and potassium serum electrolytes with the use of althesin alone and in combination with succinylcholine].

Personal experience of the behaviour of sodium, chlorine and potassium serum electrolytes in patients anaesthetized first with Althesin alone and then in association with succinylcholine is reported. Sodium and chlorine changes were slight whereas potassium concentrations fall in the first 5' before tending to rise. Used as an induction agent before succinylcholine, Althesin acts as a kind of protector against the increase in potassaemia which follows succinylcholine.

Control of renin secretion in the dog. Effects of furosemide on the vascular and macula densa receptors.

Experiments were undertaken to investigate further the effect of furosemide on renin secretion in the anesthetized dog. To separate the effects of the macula densa and the baroreceptor mechanisms, experiments were conducted in kidneys made nonfiltering by combining 2.5 hours of renal ischemia with ureteral ligation.