[Effect of some anticoagulant drugs on granulocyte capillary migration].

We have investigated the effect of four anticoagulant drugs (Calbiochem Heparin, Liquemin Roche, EDTA and Na citrate) on polymorphonuclear granulocyte capillary migration to evaluate a possible modification induced by these drugs on migration function. We can state that any modification is induced by these drugs on granulocyte capillary migration in vitro.

[Rheographic evaluation of peripheral blood flow during isometric exercise].

A rheographic evaluation of peripheral blood flow during isometric contraction (handgrip) has been done in 25 attendants of the Air Force Medical Service (mean age :20 years). The velocity of sphygmic wave, the sphygmic amplitude and, the peak time, heart rate and blood pressure have been measured at rest and during handgrip. The velocity of sphygmic wave does not change in all the subjects; the sphygmic amplitude is decreased of 10% (p less than .

[Standardization of the method of granulocyte capillary tube migration].

In the present work a method is described to standardize each step of leukocyte capillary tube migration assay. The conclusions of our study are: natrium heparin can be used as anticoagulant; the use of calibrated microcapillaries is recommended; migration chambers must lay on a horizontal surface; results can be evaluated by a ocular for radial immunodiffusion from the 16th to 20th hour of migration.

[Changes induced with varying solutions of normal plasma on granulocyte capillary tube migration].

In the present work we have evaluated the effect of decreasing concentrations of normal plasma in TC 199 on leukocyte capillary migration. From the 1st to the 4th hour of migration, normal plasma at 100%-80%-60%-40% concentration, significantly inhibits leukocyte migration. The inhibitory effect is lost, only by a few plasmas, at 60% and 40% concentration, during the following migration hours.

Therapeutic efficacy of apomorphine combined with an extracerebral inhibitor of dopamine receptors in Parkinson's disease.

Apomorphine in combination with a peripheral dopamine receptor blocker (domeperidone) was administered to four parkinsonian patients in a double-blind placebo-controlled study. The therapeutic efficacy of apomorphine was not reduced by domperidone, while nausea, drowsiness, sedation, and arterial hypotension were prevented. Combination of domperidone with dopamine agonists may result in more effective treatment of Parkinson's disease.

[Effects of isometric exercise on the pulmonary circulation in aortic patients].

The hemodynamic changes of the pulmonary vascular system in patients with aortic stenosis, has been evaluated during isometric exercise (handgrip). Heart rate, left ventricular sistolic pressure and pulmonary artery sistolic pressure, increase significantly while pulmonary vascular resistences are uneffected. In conclusion, the pulmonary response to handgrip olso in patients with aortic stenosis shows the same.

Gamma-amino-beta-hydroxy butyric acid stimulates prolactin and growth hormone release in normal women.

The influence of gamma-amino-beta-hydroxy butyric acid (GABOB) treatment on pituitary function has been investigated in this study. Different doses (50 x 100 mg) of GABOB were iv injected into three and six normal women, respectively. PRL and GH plasma levels were measured before and after the injection.

Parkinsonism by haloperidol and piribedil.

Three groups of schizophrenic patients were treated with haloperidol, with a low dose of piribedil (a dopamine agonist), and with a combination of the two treatments, respectively. After a few days, all 7 patients treated with the drug combination showed marked rigidity and akinesia, while patients treated with haloperidol alone (4) and piribedil alone (4) showed either mild or no symptoms of parkinsonism. The drug combination induced mainly an akinetic-hypertonic syndrome, while tremors were absent or mild.

[Effect of isometric exercise on the lesser circulation in a group of patients with mitral stenosis].

The hemodynamic changes of the pulmonary vascular system in patients with mitral stenosis, has been evaluated during isometric exercise (handgrip). Heart rate, pulmonary artery sistolic, dyastolic, mean and "wedged" pressure, end-dyastolic pulmonary vascular and trans-mitralic gradient, total pulmonary resistences increase significantly. Cardiac output and pulmonary vascular bed are probably related to the tachycardia induced by the handgrip, and to the conseguent shortening of the dyastolic left ventricular filling time.

Apomorphine as a preferential stimulant of self-inhibitory dopamine receptors in man.

In man, non emetic doses of apomorphine elicit a series of behavioural, neurological and psychological changes which are difficult to ascribe to the stimulation of postsynaptic dopamine receptors. Since similar effects are elicited by neuroleptic drugs, the functional changes induced by apomorphine in man might be interpreted as being the result of a decreased dopaminergic activity. The sedation and sleep, the improvement of choreic movements and the antipsychotic effect induced by non emetic doses of apomorphine are prevented by specific dopamine receptor blockers.