Background: Recently we reported IgA anti- antibodies in patients with Crohn's disease (CD), in particular in four patients from a single family of six with CD.
Methods: We studied sera from four cohorts from the north of France. These were identified as: EPIMAD (80 pediatric onset CD and 20 pediatric onset ulcerative colitis), MINOTOR (148 adult onset sporadic CD and 50 adult onset ulcerative colitis), Grande Famillies (50) and matched controls for the Grande Famillies cohort (49).