The SNARE protein SNAP-25 is required for normal exocytosis at auditory hair cell ribbon synapses.

Hearing depends on fast and sustained calcium-dependent synaptic vesicle fusion at the ribbon synapses of cochlear inner hair cells (IHCs). The implication of the canonical neuronal SNARE complex in this exocytotic process has so far remained controversial. We investigated the role of SNAP-25, a key component of this complex, in hearing, by generating and analyzing a conditional knockout mouse model allowing a targeted postnatal deletion of in IHCs.

Theobroma cacao improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia.

A gain-of-function mutation in the fibroblast growth factor receptor 3 gene (FGFR3) results in achondroplasia (ACH), the most frequent form of dwarfism. Constitutive activation of FGFR3 impairs bone formation and elongation and many signal transduction pathways. Identification of new and relevant compounds targeting the FGFR3 signaling pathway is of broad importance for the treatment of ACH, and natural plant compounds are prime drug candidate sources.

Animal models of craniosynostosis.

Background: Various animal models mimicking craniosynostosis have been developed, using mutant zebrafish and mouse. The aim of this paper is to review the different animal models for syndromic craniosynostosis and analyze what insights they have provided in our understanding of the pathophysiology of these conditions.

Material And Methods: The relevant literature for animal models of craniosynostosis was reviewed.

The PAX2-null immunophenotype defines multiple lineages with common expression signatures in benign and neoplastic oviductal epithelium.

The oviducts contain high-grade serous cancer (HGSC) precursors (serous tubal intraepithelial neoplasia or STINs), which are γ-H2AX(p) - and TP53 mutation-positive. Although they express wild-type p53, secretory cell outgrowths (SCOUTs) are associated with older age and serous cancer; moreover, both STINs and SCOUTs share a loss of PAX2 expression (PAX2(n) ). We evaluated PAX2 expression in proliferating adult and embryonic oviductal cells, normal mucosa, SCOUTs, Walthard cell nests (WCNs), STINs, and HGSCs, and the expression of genes chosen empirically or from SCOUT expression arrays.

X-ray line polarization of He-like Si satellite spectra in plasmas driven by high-intensity ultrashort pulsed lasers.

We present a modeling study of x-ray line polarization in plasmas driven by high-intensity, ultrashort duration pulsed lasers. Electron kinetics simulations of these transient and nonequilibrium plasmas predict non-Maxwellian and anisotropic electron distribution functions. Under these conditions, the magnetic sublevels within fine structure levels can be unequally populated which leads to the emission of polarized lines.

Dielectronic Spectra for Ne-like Ions from F-like Low-Lying States.

Energy levels, radiative decay, and Auger rates have been calculated for dielectronic recombination of seven Ne-like ions, ranging from Fel7+ to Ag38+, from the n = 2 F-like shell into the n = 3 one, by use of the multiconfiguration AUTOLSJ code in intermediate coupling. Rate coefficients have then been computed versus the electronic temperature, the nuclear charge of the involved element, the final Ne-like state, and the population distribution among the initial 3 F-like levels. Dielectronic spectra have also been obtained.

The abstraction of a central tendency in amnesic patients.

Amnesic patients and control subjects were asked to reproduce arm movements of a given amplitude and to average amplitudes on series of three such movements. The error in averaging was found to be equal in patients and control subjects while reproduction performance was clearly affected by amnesia. The implications of these data for a theory of amnesia are briefly discussed.