Publications by authors named "Cornelius Magut"
Article Synopsis
- The study aimed to evaluate the prevalence of cryptococcal antigen (CrAg) in a group of African adults and children with low CD4+ cell counts, and its relationship to mortality rates and new cases of cryptococcal disease in the REALITY trial.
- Researchers conducted retrospective testing on plasma samples from participants who were either given enhanced prophylaxis or standard treatment while starting antiretroviral therapy.
- Findings indicated that enhanced prophylaxis led to fewer deaths and new cases of cryptococcal disease regardless of the initial CrAg positivity status, implying that treatment effectiveness was consistent across different baseline conditions.
Objective: Kenya, like many resource-constrained countries, has a single mycobacterial laboratory, centrally located in Nairobi, with capacity for drug-susceptibility testing (DST) - the gold standard in diagnosing drug-resistant tuberculosis. We describe and evaluate a novel operational design that attempts to overcome diagnostic delivery barriers.
Methods: Review of the public DST programme identified several barriers limiting access: lack of programme awareness amongst physicians, limited supplies, unreliable transport and no specimen tracking methods.