Micro-CT Microcalcification Analysis: A Scoping Review of Current Applications and Future Potential in Breast Cancer Research.

Micro-computed tomography (micro-CT) is a non-destructive imaging technique that offers highly detailed, 3D visualizations of a target specimen. In the context of breast cancer, micro-CT has emerged as a promising tool for analyzing microcalcifications (MCs), tiny calcium deposits that can indicate at an early stage the presence of cancer. This review aimed to explore the current applications of micro-CT in analyzing breast MCs (ex vivo, animal models, and phantoms) and to identify potential avenues in scientific research.

Baseline Survey on Referrals and Healthcare Provider Needs in View for an Electronic Referral System.

The study aimed to evaluate the formats and completeness of the current paper-based referral system and assess user needs for designing an electronic referral system. Conducted in eight public health facilities in Kigali city, the mixed methods approach identified seven different referral letter formats, with the external transfer form averaging 58.8% completeness.

Remote Patient Monitoring at Home in Patients With COVID-19: Narrative Review.

Background: During the pandemic, health care providers implemented remote patient monitoring (RPM) for patients experiencing COVID-19. RPM is an interaction between health care professionals and patients who are in different locations, in which certain patient functioning parameters are assessed and followed up for a certain duration of time. The implementation of RPM in these patients aimed to reduce the strain on hospitals and primary care.

Evaluation of a Computer-Aided Clinical Decision Support System for Point-of-Care Use in Low-Resource Primary Care Settings: Acceptability Evaluation Study.

Background: A clinical decision support system (CDSS) based on the logic and philosophy of clinical pathways is critical for managing the quality of health care and for standardizing care processes. Using such a system at a point-of-care setting is becoming more frequent these days. However, in a low-resource setting (LRS), such systems are frequently overlooked.

Economic evaluation of intensive home treatment in comparison to care as usual alongside a randomised controlled trial.

Background: There is a dearth of research on the cost-effectiveness of intensive home treatment (IHT), an alternative to psychiatric hospitalisation for patients experiencing psychiatric crises. We therefore present a health economic evaluation alongside a pre-randomised controlled trial of IHT compared to care as usual (CAU).

Method: Patients were pre-randomised to IHT or CAU using a double-consent open-label Zelen design.

Prescriptive factors for intensive home treatment in acute psychiatry: a secondary analysis of a randomised controlled trial.

Background: Intensive home treatment (IHT) aims to prevent psychiatric hospitalisation. Although this intervention is well tested, it is still unknown for whom this intervention works best. Therefore, this study aims to explore prescriptive factors that moderate the effect of IHT compared to care as usual (CAU) on symptom severity.

Congenital giant right atrial aneurysm.

Right atrial aneurysm is a rare congenital heart condition defined as a dilation of the right atrium in the absence of an underlying cause [1]. The clinical presentation varies; most patients are asymptomatic, while others may experience arrhythmias or intracavitary thrombi [1, 2]. We report a case.

Poor Subjective Sleep Quality Predicts Symptoms in Irritable Bowel Syndrome Using the Experience Sampling Method.

Introduction: Sleep quality may affect symptom experience in irritable bowel syndrome (IBS). Our aim was to investigate the relationship between sleep quality and gastrointestinal (GI) symptoms using actigraphy and the experience sampling method.

Methods: Patients with IBS were recruited from a tertiary Neurogastroenterology clinic and the community.

The impact of (simulated) resolution on breast cancer diagnosis based on high-resolution 3D micro-CT microcalcification images.

Background: Breast microcalcifications (MCs) are considered to be a robust marker of breast cancer. A machine learning model can provide breast cancer diagnosis based on properties of individual MCs - if their characteristics are captured at high resolution and in 3D.

Purpose: The main purpose of the study was to explore the impact of image resolution (8 µm, 16 µm, 32 µm, 64 µm) when diagnosing breast cancer using radiomics features extracted from individual high resolution 3D micro-CT MC images.

Climatic water availability modifies tree functional diversity effects on soil organic carbon storage in European forests.

Forest stand and environmental factors influence soil organic carbon (SOC) storage, but little is known about their relative impacts in different soil layers. Moreover, how environmental factors modulate the impact of stand factors, particularly species mixing, on SOC storage, is largely unexplored. In this study, conducted in 21 forest triplets (two monocultures of different species and their mixture on the same site) distributed in Europe, we tested the hypothesis that stand factors (functional identity and diversity) have stronger effects on topsoil (FF + 0-10 cm) C storage than environmental factors (climatic water availability, clay + silt content, oxalate-extractable Al-Al) but that the opposite occurs in the subsoil (10-40 cm).

Evaluating a clinical decision support point of care instrument in low resource setting.

Background: Clinical pathways are one of the main tools to manage the health care's quality and concerned with the standardization of care processes. They have been used to help frontline healthcare workers by presenting summarized evidence and generating clinical workflows involving a series of tasks performed by various people within and between work environments to deliver care. Integrating clinical pathways into Clinical Decision Support Systems (CDSSs) is a common practice today.

Circulating Reactive Oxygen Species in Adults with Congenital Heart Disease.

Oxidative stress is an important pathophysiological mechanism in the development of numerous cardiovascular disorders, but few studies have examined the levels of oxidative stress in adults with congenital heart disease (CHD). The objective of this study was to investigate oxidative stress levels in adults with CHD and the association with inflammation, exercise capacity and endothelial function. To this end, 36 adults with different types of CHD and 36 age- and gender-matched healthy controls were enrolled.

Improving hospital nurse staffing during the pandemic: Implementation of the 2019 Fund for Health Care Staff in Belgium.

Chronic hospital nurse understaffing is a pre-existing condition of the COVID-19 pandemic. With nurses on the frontline against the pandemic, safe nurse staffing in hospitals is high on the political agenda of the responsible ministers of Health. This paper presents a recent Belgian policy reform to improve nurse staffing levels.

Assessment of formats and completeness of paper-based referral letters among urban hospitals in Rwanda: a retrospective baseline study.

Background: Patient referral is a process in which a healthcare provider decides to seek assistance due to the limitations of available skills, resources and services offered locally. Paper-based referrals predominantly used in low-income countries hardly follow any procedure. This causes a major gap in communication, coordination, and continuity of care between primary and specialized levels, leading to poor access, delay, duplication and unnecessary costs.

The cumulative effect of chronic stress and depressive symptoms affects heart rate in a working population.

Background: Chronic stress and depressive symptoms have both been linked to increased heart rate (HR) and reduced HR variability. However, up to date, it is not clear whether chronic stress, the mechanisms intrinsic to depression or a combination of both cause these alterations. Subclinical cases may help to answer these questions.

If All Else Fails: Impact of Silicon Accumulation in Maize Leaves on Volatile Emissions and Oviposition Site Selection of Spodoptera exigua Hübner.

Silicon (Si) fertilization alleviates biotic stresses in plants. Si enhances plant resistance against phytophagous insects through physical and biochemical mechanisms. In particular, Si modifies jasmonic acid levels and the emissions of herbivore-induced plant volatiles (HIPVs).

Experiences with the implementation of remote monitoring in patients with COVID-19: A qualitative study with patients and healthcare professionals.

Introduction: This study investigated how patients with COVID-19, telemonitoring (TM) teams, general practitioners (GPs) and primary care nurses in Belgium experienced remote patient monitoring (RPM) in 12 healthcare organizations, in relation to the patients' illness, health, and care needs, perceived quality of care, patient and health system outcomes, and implementation challenges.

Design: A qualitative research approach was adopted, including focus group discussions and semi-structured interviews.

Methods: Four different groups of participants were interviewed, that is, patients (n = 17), TM teams (n = 27), GPs (n = 16), and primary care nurses (n = 12).

Congenitally corrected transposition of the great arteries outcomes of different surgical techniques in a paediatric population: A single-centre report.

Background: Congenitally corrected transposition of the great arteries is a complex pathology characterised by atrioventricular and ventriculo-arterial discordance. Optimal surgical approaches are still a matter of debate.

Objective: To evaluate the outcomes of different surgical treatments in a single centre.

A Hybrid Approach for Designing Dynamic and Data-Driven Clinical Pathways Point of Care Instruments in Low Resource Settings.

Though a clinical pathway is one of the tools used to guide evidence-based healthcare, promoting the practice of evidence-based decisions on healthcare services is incredibly challenging in low resource settings (LRS). This paper proposed a novel approach for designing an automated and dynamic generation of clinical pathways (CPs) in LRS through a hybrid (knowledge-based and data-driven based) algorithm that works with limited clinical input and can be updated whenever new information is available. Our proposed approach dynamically maps and validate the knowledge-based clinical pathways with the local context and historical evidence to deliver a multi-criteria decision analysis (concordance table) for adjusting or readjusting the order of knowledge-based CPs decision priority.

The distribution of carbon stocks between tree woody biomass and soil differs between Scots pine and broadleaved species (beech, oak) in European forests.

Unlabelled: While the impacts of forest management options on carbon (C) storage are well documented, the way they affect C distribution among ecosystem components remains poorly investigated. Yet, partitioning of total forest C stocks, particularly between aboveground woody biomass and the soil, greatly impacts the stability of C stocks against disturbances in forest ecosystems. This study assessed the impact of species composition and stand density on C storage in aboveground woody biomass (stem + branches), coarse roots, and soil, and their partitioning in pure and mixed forests in Europe.

Real-Time Analysis of Hand Gesture Recognition with Temporal Convolutional Networks.

In recent years, the successful application of Deep Learning methods to classification problems has had a huge impact in many domains. (1) Background: In biomedical engineering, the problem of gesture recognition based on electromyography is often addressed as an image classification problem using Convolutional Neural Networks. Recently, a specific class of these models called Temporal Convolutional Networks (TCNs) has been successfully applied to this task.

Improved automated early detection of breast cancer based on high resolution 3D micro-CT microcalcification images.

Background: The detection of suspicious microcalcifications on mammography represents one of the earliest signs of a malignant breast tumor. Assessing microcalcifications' characteristics based on their appearance on 2D breast imaging modalities is in many cases challenging for radiologists. The aims of this study were to: (a) analyse the association of shape and texture properties of breast microcalcifications (extracted by scanning breast tissue with a high resolution 3D scanner) with malignancy, (b) evaluate microcalcifications' potential to diagnose benign/malignant patients.