Publications by authors named "Cornelis J Sanders"
Article Synopsis
- The study examined nine patients with the same genetic mutation (homozygous R169Q in CECR1) linked to adenosine deaminase-2 (ADA2) deficiency, analyzing clinical symptoms and diagnostic data.
- The clinical presentation varied widely among patients, with most experiencing symptoms like splenomegaly, skin issues, and neurological problems, including strokes, as well as other significant health complications.
- Findings suggest that even with identical mutations, factors such as epigenetics and environment significantly influence disease severity, with haematopoietic cell transplantation showing potential in improving patient outcomes.
Background: Topical 5-fluorouracil 5% cream is one of the treatment modalities for non-melanoma skin cancer (NMSC). There is a lack of suitable therapies to treat patients with extensive NMSC. In this paper we report two patients with extensive NMSC treated by total body application of topical 5-fluorouracil 5% cream.
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