Publications by authors named "Cornelis Am de Haan"
Prevalence of elephant endotheliotropic herpesvirus (EEHV) infections in Asian elephants in Japan was assessed by determination of EEHV gB specific antibody levels. Among 28 healthy Asian (sub) adult elephants from 11 zoos, 27 animals exhibited intermediate to high antibody levels. Like elsewhere worldwide, this suggested exposure of Asian elephants in Japan to at least one EEHV (sub) species.
View Article and Find Full Text PDFInfluenza A viruses (IAVs) originating from animal reservoirs pose continuous threats to human health as demonstrated by the Spanish flu pandemic. Infection starts by attachment to host receptors, a crucial step that is targeted by immunological, prophylactic, and therapeutic intervention. Fine-tuning of virus hemagglutinin binding to host-specific receptor repertoires needs to remain balanced to receptor-destroying neuraminidase (NA) activity and is a key step in host adaptation.
View Article and Find Full Text PDFNatural killer cell activation by respiratory syncytial virus-specific antibodies is decreased in infants with severe respiratory infections and correlates with Fc-glycosylation.
Clin Transl Immunology
February 2020
Article Synopsis
- RSV (Respiratory syncytial virus) is a leading cause of severe respiratory infections in infants, highlighting the need for better understanding of maternal antibodies and their role in protection.
- Antibody levels alone do not effectively correlate with protection against RSV; instead, the ability of antibodies to activate natural killer (NK) cells may be more critical.
- The study suggests that the quality of antibodies, particularly their Fc-glycosylation status, affects NK cell activation and may play a significant role in protecting against severe RSV disease, indicating potential avenues for vaccine improvement.