Publications by authors named "Cornelia Weinhold"
Article Synopsis
- Diarrhea often occurs in intestinal diseases characterized by low blood flow or oxygen (ischemia and hypoxia), leading to disruptions in chloride and fluid transport.
- Research found that low oxygen levels decrease the expression and function of the cystic fibrosis transmembrane conductance regulator (CFTR), a key protein in fluid regulation in the intestines, through the action of hypoxia-inducible factor-1 (HIF-1).
- Experiments in mice showed that HIF-1 significantly impacts CFTR expression and, consequently, the body's ability to control fluid secretion in response to low oxygen conditions.
